Benefits Of Probiotics In Rheumatic Diseases
- 1Rheumatology Unit, Department of MedicineDIMED, University of Padova, Padua, Italy
- 2Clinical Nutrition Unit, Department of MedicineDIMED, University of Padova, Padua, Italy
Rheumatic diseases are chronic conditions which affect a large proportion of the population worldwide . Among them, inflammatory chronic diseases including rheumatoid arthritis , spondyloarthritis , crystal-induced arthritis , and connective tissue autoimmune diseases, such as systemic lupus erythematosus and systemic sclerosis , are the most common. Chronic inflammation has been recognized to play a role also in osteoarthritis , classically considered a non-inflammatory form of arthritis.
Although different risk factors influence their onset and development, these heterogeneous conditions share common clinical outcome including joint pain, disability, and comorbidities .
The most commonly used are Lactobacilli , Bifidobacteria , and Streptococci , either as single species or in mixed culture. Their health effects are largely recognized and supported by randomized controlled clinical trials and meta-analyses conducted on infectious diseases, antibiotic-associated diarrhea, irritable bowel syndrome, abdominal pain, and colitis .
Preparation Of Lactobacillus Gasseri Pa3 Supplements
Lactobacillus gasseri PA3 with an ability of purine absorption was isolated from Lactobacillus gasseri PA3 drinking yogurt by the method of Jang et al. and cultured in Man Rogosa Sharpe liquid medium at 37°C for 48 hr. MRS : peptone 10.0, beef extract 5.0, glucose 20.0, Tween 80 1.0, dipotassium phosphate 2.0, sodium acetate 5.0, triammonium citrate 2.0, magnesium sulfate 0.2, manganese sulfate 0.05, and agar powder 14.5. After 15 min of centrifugation at 6,000g, supernatant was discarded and isometric fermented nutritive medium was added to suspend the cells. FNM is composed of: peptone 3.0, corn starch 8.0, yeast extract 4.5, tryptone 3.0, Mucin 0.5, l-cysteine hydrochloride 0.8, bile No.3 0.4, heme 0.05, sodium chloride 4.5, Tween 80 1.0, potassium chloride 2.5, potassium dihydrogen phosphate 0.4, magnesium chloride hexahydrate 4.5, calcium chloride hexahydrate 0.2, and 2 ml of trace elements stock solution .
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Metagenomic Analysis Shows That The Gut Microbiome May Have A Role In Gout
Compared with healthy individuals, patients with gout were found to have a significantly unique gut microbiota associated with dysregulated host urate degradation and systemic inflammation, according to study results published in NPJ Biofilms and Microbiomes.
Given the growing evidence suggesting a link between the gut microbiome and arthritis, Chu and colleagues sought to investigate the taxonomic and functional signatures of the gout microbiome, its association with gout-related clinical parameters, response to therapeutic interventions, and identification of gout-specific microbiome signatures compared with the other autoimmune and metabolic disorders.
In the current large-scale metagenomic analysis, the researchers examined the gut microbiome of 307 fecal samples collected longitudinally from 102 patients with gout and 86 healthy individuals. The study group included 2 cohorts the discovery cohort included 140 samples at baseline and 70, 40, and 9 fecal samples collected longitudinally from patients with gout at week 2, 4, and 24 post-baseline, respectively the validation cohort included 48 samples .
Using a random forest model, the researchers constructed a disease classifier based on the microbial gene-level profile. Three genes were significantly enriched in patients with gout in the discovery cohort , and 2 of the genes showed an increasing trend in the validation cohort .
Reference
Can Microbiomes Treat Gout One Day
Ever since Barry Davis contacted me and agreed to write the guest post on his personal bout with gout, and how he thinks that parasite bacteria in our gut may be the root cause of gout, I have been doing more research on the subject and my findings will surprise you. For those who havent read Barrys post, I recommend that you do before continuing reading this post.
Although my research didnt find anything relating gout with a leaky gut, there is a lot of evidence relating leaky gut with autoimmune diseases like rheumatoid arthritis and psoriasis, which are closely related to gout.
So what is a leaky gut? I found the best definition in Dr.Weils site:
Leaky gut syndrome is not generally recognized by conventional physicians, but evidence is accumulating that it is a real condition that affects the lining of the intestines. The theory is that leaky gut syndrome , is the result of damage to the intestinal lining, making it less able to protect the internal environment as well as to filter needed nutrients and other biological substances.
In a 2021 study published in NPJ Biofilms and Microbiomes found that compared to healthy individuals, patients with gout were found to have a significantly unique gut microbiota associated with dysregulated host urate degradation and systemic inflammation.
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Does Epsom Salt Help Gout
Yes, epsom salt help gout sufferers. You can also try epsom salt to treat gout. Add 2 cups of it to the full bathtub and spend 10-15 minutes in it. You can also target only affected areas such as big toe .
Warm water is ideal because it will open the skin pores and allow the salt penetrate the skin. For even better results use magnesium supplements.
Be free to repeat the process as many times as you like. There are no side effects of using epsom salt. It can help you with pain relief or nothing will happen. An interesting fact is that you can get smooth and softer skin from using epsom salt while taking a bath. Who knows, maybe it helps you dramatically and it becomes the ultimate gout remedy that you will recommend to everyone.
How Probiotics Treat Acid Reflux
While you can see how probiotics supplements are becoming so popular, what you really want to know is how probiotics help acid reflux. This is one of those areas where science is still very actively studying the results of probiotics on acid reflux, but there are some theories why this natural remedy works.
Prevent fermentation: One theory is that an overgrowth of the bad bacteria in your stomach causes fermentation, resulting in extra gas. The belief is that these gas forces open the lower esophageal sphincter, which then allows acid and other stomach contents to flow upward into the esophagus.
The use of probiotics balances out the good and bad bacteria in the body, reducing the gas and eliminating fermentation.
The stomach works faster: Probiotics may promote faster absorption and stomach emptying. Many sufferers of acid reflux report that they suffer more symptoms after overeating.
This full-stomach feeling may be emotionally satisfying but it makes it much easier for food to back up into the esophagus. When your stomach empties faster, youre closing the window on regurgitation and other GERD symptoms.
When acid reflux reaches the point of GERD, or when it continually creeps up into the esophagus, the lining is irritated and inflammation results. Probiotics have anti-inflammatory properties and can ease these acid reflux symptoms, provided you buy one with the right probiotic strains.
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Spotting Physiology In Everyday Life
The number of people who develop long-term health problems such as obesity, high blood pressure and kidney disease increases every year. Because these chronic conditions affect so many, it is important to better understand what causes them.
International scientists who study the kidneys, heart, blood vessels and other organs recently gathered to discuss the relationship between a hormone , a protein and a cell membrane pathway that work together to regulate the bodys balance of salt and water.
When one or more of these factors is out of balance, it can affect your health in a number of ways. Many of the new findings presented could affect how doctors treat disorders like heart disease, high blood pressure, high cholesterol and high blood sugar. Researchers also discussed how men and women may need slightly different treatments because they react differently.
Researchers also discussed:
What Is Acid Reflux
Acid reflux is when acid and other stomach contents come back up the esophagus. This can cause heartburn, chest pain, and regurgitation. If your acid reflux symptoms occur more than twice a week, you may have progressed to having a condition called gastroesophageal reflux disease, otherwise known as GERD.
If your acid reflux has reached this level you may encounter more symptoms, such as:
Bloating
Coughing
Dysphagia, narrowing of the esophagus
If you have acid reflux or feel that youve progressed to GERD, its important to see a medical health professional.
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High Potency Micro Encapsulated Probiotic
Gout CareFriendly Fighters Pro®Friendly Fighters®
| 3 Uniquely Selected, Viable Strains2 Billion Cells Per Vege-capAvailable in 3 bottle sizes1-month, 3-month, or 4-month supply option | 30 capsules per bottle- 30 day supply – Over 70% of your immune system is in your digestive tract. Do you have enough friendly bacteria to handle this large task? | 90 day supply – The bowels are responsible for almost 30% of all Uric Acid elimination. Friendly bacteria is essential to this process. The combination of Probiotics and GC® GoutCare will equip you with the tools necessary to fight and eliminate uric acid build up. | Probiotic therapy is commonly used in the treatment of acne, eczema, psoriasis, migraine, allergies, Gout, rheumatic and arthritic conditions, candidiasis, cystitis, colitis, irritable bowel syndrome, Crohn’s disease, and even some forms of cancer. |
Probiotic therapy Who should take a Probiotic?
Additional Tips For Treating Gout Naturally
Studies show that many of the dietary items we consume lead to gout as well as other health problems. Changing your diet and lifestyle may be the easy solution to beating gout. One of the first things to do is eliminate certain foods and beverages from your diet to beat gout.
1. Eliminate or reduce sugar intake
As many studies are now illustrating, gout is common in people with excessive sugar intake, especially high fructose corn syrup Its wise to read the labels of all your food and drinks. If you find HFCS then eliminate that from your diet. In addition, look for sugar added under the guise of other common names for sugar look for cose at the end of words and these are probably types of sugar you dont want to be consuming.
2. Eliminate grains
Grains in the body are converted to sugars so again you want to limit or avoid grains altogether. They are also very inflammatory to your body.
3. Limit alcohol consumption
Again, alcohol becomes sugar once ingested so eliminate this completely unless you have a healthy body already. Any substance that will be converted to one or another type of sugar by the body should be avoided at all costs. In order to get your uric acid levels down you must consistently avoid sugar in your diet.
4. Eliminate soda and diet soda
5. Consume cherries and strawberries daily
6. Exercise
If you want to learn more natural remedies and natural cures, subscribe to my YouTube channel.
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Are There Any Evidences Supporting The Role Of Probiotics In Rheumatic Diseases
Although still limited, there’s a growing interest in the possible use of probiotics in rheumatic diseases. We discuss here the evidence deriving from RCTs conducted in chronic conditions including RA, OA, gout, and SpA . These studies have been addressed to the investigation of the effect of oral probiotic administration in ameliorating systemic inflammatory markers and disease activity indices.
Table 1. Randomized clinical trials carried out on the effect of probiotics in rheumatic diseases.
Why I Like It
For its price, this is a great probiotic supplement making it a top value buy.
Another solid feature is that the bacteria used in this supplement allow good bacteria to flourish in your gut, and help prevent the growth of bad bacteria.
This will help reduce inflammation, which should help improve Gout symptoms.
Im also a big, big fan of Doctors Best as a supplement company.
Theyre one of the most trustworthy brands out there in quite a shady industry.
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Choose The Right Kind Of Probiotic
There are a number of different kinds of probiotics to choose from. Some people benefit from taking lactic-acid probiotics like Lactobacillus or Bifidobacterium, while others do better with yeast-derived probiotics like Saccharomyces boulardii or soil-based organisms like Bacillus. For some people, a combination of all three probiotic types is ideal.
Avoid Consuming Large Amounts Of Food High In Purines
Purines are chemical compounds found in some foods and drinks.
Gout sufferers find the chemical harder to metabolise, so avoiding consuming large amounts of high purine foods is advisable.
Beef, lamb, game, offal, and some seafoods such as mackerel, mussels, anchovies, sardines, crab and herring are all examples.
High-fat dairy products, yeast, beer and gravy are also sources.3,4
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Drink Plenty Of Water
Drinking extra fluids can help your kidneys more quickly dispense of excess uric acid via your urine, says Elizabeth Volkmann, MD, a rheumatologist and translational researcher at UCLA Health.
Women should aim to drink at least 90 ounces of water a day, and men need 125 ounces, according to the Food and Nutrition Board. Aim for at least that much, or a little more, to ensure your kidneys can do their thing. Coffee can also increase uric acid excretion, Dr. Volkmann says.
Comparison Of Gut Metagenome Between Gout And Other Autoimmune And Metabolic Disorders
Fig. 6: Comparison of gut microbiome between gout and other autoimmune and metabolic diseases.
a The distribution of P values by Wilcoxon rank-sum test for all microbial genes in case-control comparison within each of the AS , gout , OB , RA , and T2D datasets. b Comparison of differential species in AS, gout, OB, RA and T2D. Purple, enriched in healthy controls red, enriched in patients Wilcoxon rank-sum test: asterisk denotes FDR P< 0.05. c Comparison of microbial gene functions in AS, gout, OB, RA and T2D. Purple, enriched in healthy controls red, enriched in patients. Asterisk denotes reporter score of pathways> 1.65 or< 1.65.
You can also search for this author inPubMed
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How Can Gout Be Managed
If you do develop gout in a joint, rest it and ice it. You can take Ibuprofen to manage the pain and reduce inflammation but unless you need to take Aspirin for another health problem, you should avoid it, as it can actually increase uric acid levels and make the gout worse.
If you do need to take Aspirin while suffering with gout, consult your doctor about appropriate doses and the best ways to manage the problem. Advice from the Gout Society, is that low doses when prescribed for prevention of heart attacks should not increase your uric acid levels significantly and should be continued.
If gout persists, your doctor can help with ways to manage the pain better or by prescribing medication to control your uric acid levels.
Effect Of Lactobacillus Gasseri Pa3 On Gut Microbiota In An In Vitro Colonic Simulation
School of Food Science and Bioengineering, Zhejiang Gongshang University, Hangzhou, China
Correspondence
Xuan Zhu, School of Food Science and Bioengineering, Zhejiang Gongshang University, No. 18 Xuezheng Str., Hangzhou, Zhejiang Province 310018, China.
School of Food Science and Bioengineering, Zhejiang Gongshang University, Hangzhou, China
Correspondence
Xuan Zhu, School of Food Science and Bioengineering, Zhejiang Gongshang University, No. 18 Xuezheng Str., Hangzhou, Zhejiang Province 310018, China.
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Foods That Offer A Probiotic Boost
While definitive connections between the gut microbiome and RA have yet to be confirmed, it can’t hurt for you to introduce healthful probiotics into your system via healthy foods.
Bonnie Taub-Dix, RDN, the author of Read It Before You Eat It Taking You From Label to Table, says, Its better to get probiotics through real, whole foods rather than supplements. They don’t only contain probiotics food also contains an array of other nutrients that are important for good health, like vitamins and minerals. Whole foods also boost satiety and reduce appetite because of their high fiber content, she says.
To up your probiotic intake, chow down on fermented foods, such as pickles, sauerkraut, kimchi, yogurt with live cultures, and kefir.
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Overview Of Gut Metagenome In Gout Patients And Controls
We performed metagenomic shotgun sequencing for 307 fecal samples collected from 188 individuals. At baseline, there were 140 samples in discovery cohort collected during 20162017, including 77 gout patients and 63 healthy controls. There were 48 samples in validation cohort collected in the year of 2018, consisting of 25 gout patients and 23 healthy controls. In addition, 70, 40, and 9 fecal samples were collected from gout patients in discovery cohort longitudinally at three follow-up time points , to assess the effects of therapeutic intervention on the gut microbiome in gout patients. All patients information is summarized in Supplementary Data . Compared with controls, gout patients had elevated levels of inflammation and renal indices, including C-reactive protein , erythrocyte sedimentation rate , SUA, and serum creatinine . There was a higher body mass index in gout patients, in accordance with the view that gout was associated with obesity. In addition, CRP, ESR, SUA, and other gout-associated indices including visual analog scale , arthralgia, joint swelling scores and joint tenderness scores declined in gout patients following treatment .
Table 1 The baseline characteristics of subjects in discovery and validation cohorts.Fig. 1: Gut microbial alterations in gout patients.
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