Thursday, April 11, 2024

Probiotics With Lactobacillus Rhamnosus And Lactobacillus Reuteri

Gm And Bone Health Beyond Immune System

Lactobacillus rhamnosus (LGG®) – the world’s best documented probiotic strain

GM composition and manipulation may affect bone health by influencing calcium absorption and the production of gut-derived serotonin . Lactobacillus reuteri in healthy subjects increases the level of serum 25OH vitamin D that influences calcium absorption and benefits bone health. The mechanism through which this probiotic influences vitamin D level is not clear. This may be due to a modification in the gut environment that specifically favors vitamin D absorption or to indirect effect on increased hepatic 25-hydroxylase activity or 7-dehydrocholesterol concentration, due to reduced absorption of dietary and biliary cholesterol .

Another possible mechanism through which GM influences bone health is mediated by its effect on the production of gut serotonin . In the recent past a dual effect of serotonin in the regulation of bone mass has been described, depending on the site of production of this molecule . A role as a bone mass regulator was proposed to gut-derived 5HT , which is influenced by GM. Enterochromaffin cells of the duodenum are responsible for the synthesis of g5HT, which is partially modulated by GM, as SCFAs increase the synthesis of g5HT . It has been shown that 5HT interacts with bone cells and, in particular, decreases osteoblast proliferation. These observations suggest that regulation of g5HT by GM may be a potential therapeutic strategy to improve bone health.

The relationship between GM and bone beyond immune system is summarized in Fig. 35.3.

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L Reuteri And Oxytocin In Muscle Wasting And Bone Loss

We recently reported that L. reuteri counteracts age-associated sarcopenia- and cancer-induced cachexia . The beneficial effects on skeletal muscle coexisted with increased growth hormone levels, decreased systemic inflammatory tone, and increased Forkhead Box N1 expression in the thymus gland. FoxN1-deficient mice fail to inhibit sarcopenia after L. reuteri consumption, suggesting a FoxN1-mediated mechanism .

Oxytocin has also a trophic effect in skeletal muscle . Experiments in mice show that plasma levels of oxytocin naturally decrease with age and that the hormone is necessary for muscle tissue regeneration. Oxytocin-deficient mice develop premature sarcopenia, while the administration of an oxytocin antagonist reduces muscle regeneration. By contrast, systemic administration of oxytocin activates the MAPK/ERK signaling pathway to promote aged muscle stem cell activation/proliferation and muscle regeneration .

Several studies in mice demonstrate that L. reuteri increases bone density and prevents bone loss in both menopausal ovariectomized and type 1 diabetes mouse models . In the female-ovariectomized mice, the L. reuteri effects are mediated by the suppression of effector CD4 + T-cell-mediated osteoclastogenesis . In the male diabetic mice L. reuteri inhibited the TNF–induced reduction of osteoblast number and activity .

H. Ahanchian, A. Javid, in, 2017

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Our Probiotic Strains With L Reuteri

L. reuteri Protectis

  • For gut comfort
  • 152 completed clinical trials in 14 800 individuals

L. reuteri Prodentis

  • For gums and teeth
  • 42 completed clinical trials in 2 065 individuals

L. reuteri Gastrus

  • For GI tract

L. reuteri Osfortis

  • For bone health

L. reuteri Colus

  • This product is still under development for colon health.
  • 1 clinical trial

Growth Media And Culture Conditions


Both probiotic lactobacilli strains were routinely cultured on de Man, Rogosa and Sharpe agar and incubated anaerobically for 48 h at 37°C. Subsequently, lactobacilli strains were inoculated into MRS broth and incubated anaerobically for 24 h at 37°C in an orbital shaker . All of the C. glabrata strains were cultured on Yeast Extract-Peptone-Dextrose agar and incubated aerobically for 24 h at 37°C. Candida glabrata colonies were transferred into YPD broth and incubated aerobically for 24 h at 37°C in an orbital shaker .

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Strains And Culture Conditions

The Candida albicans and bacterial strains used in this study are listed in Table 1. Stock cultures of all strains were stored at 80°C with 15% v/v glycerol as cryopreservative. C. albicans was routinely grown in YPD media . For coculture assays, C. albicans was grown in the same media as lactobacilli and staphylococci, that is, Difco Lactobacilli MRS broth . Regular agar plates contained 15g/L Agar while 7g/L of agar were used in soft agar overlays. Standard incubation conditions for pure yeast cultures were 30°C and ambient aeration. Bacteria were grown at 37°C under a 5% CO2 atmosphere in a CO2 incubator. Bacteria-Candida cocultures were incubated as indicated in a CO2 incubator or in ambient air at 37°C growth temperature.

What Are The Benefits Of Taking Probiotics

Probiotic supplements have been shown to benefit health in a number of ways.

However, some of the purported benefits of probiotics arent supported by research, so its important to always consult a healthcare professional before taking a probiotic supplement, especially if youre hoping to improve symptoms related to a health condition.

Recommended Reading: Does A Probiotic Make You Poop

In Vitro Growth Inhibition

The rich MRS medium was chosen for these experiments because it supported vigorous growth by the Lactobacillus, Staphylococcus aureus, and C. albicans strains. Agar overlays of C. albicans on MRS plates inoculated with the probiotic lactobacilli and control bacteria represented a relatively simple screening method for growth inhibitory activities of the bacteria towards this yeast. The deferred assay regimen with a 2-day preincubation of the bacteria was the method of choice because simultaneous inoculation often led to no or very small bacterial colonies due to rapid overgrowth by the fungal cells.

Inhibition of C. albicans growth by lactic acid at low pH. Microplate growth assays were used to determine the effect of lactic acid on the growth of C. albicans. MRS medium was supplemented with 120mM lactic acid and the pH was adjusted to pH 4.5 or 7.0. MRS with 120mM lactic acid had a pH of 4.2. As a control for low pH, MRS was adjusted to pH 4.5 using hydrochloric acid ). While acidic pH slows growth of C. albicans, the strongest growth inhibition was achieved with lactic acid at low pH. This inhibitory effect was completely lost by neutralization. Error bars show the standard deviations of two experiments with quadruplicate measurements. Statistical significant differences to all other conditions as calculated by ANOVA are indicated by asterisks.

How To Take Biomemd For Women

Treating infant colic with the probiotic Lactobacillus reuteri

As a dietary supplement, adults take one capsule, once daily, preferably with a food containing fiber, or as recommended by a healthcare practitioner.

The views/opinions expressed by contributors and/or product reviews are their own and not necessarily those of These reviews should not be taken as recommendations but rather customer opinions of the products that they have used. The real 1MD Nutrition customers featured in our videos were compensated for their time. Results may vary. Furthermore, makes no warranty or representation, expressed or implied, as to the accuracy or sufficiency of the information contributed by outside sources, and assumes no responsibility or liability regarding the use of such information. All doctors mentioned and/or featured on this site are paid partners of 1MD Nutrition. The statements on this site have not been evaluated by the FDA. The information provided in content sections, customer reviews and testimonials is intended for educational purposes only. Products sold on are not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, nursing, taking medication, have a medical condition, or are under the age of 18, consult your physician before using this product. Immediately discontinue use and consult your physician if you experience any adverse reaction to this product.

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Summarized Tips On Why You Should Buy From An Online Marketplace

In the year 2022, you have a multitude of options everytime you look to buy a new product. You have traditional retailers, department stores, online marketplaces, etc. We believe that for your next purchase, you should seriously consider online marketplaces.

Online platforms come with loads of facilities designed to make your entire shopping experience better. They are reputable, well regarded, and provide you with the opportunity to shop from your home and get the best deals.

A very important thing you get when buying from an online platform is flexibility and convenience. In our busy lives, it is quite hard to find the time to visit a physical store. Meanwhile, you can buy anything you want, including probiotics rhamnosus reuteri from an online store, while you are taking a break at work or doing your chores.

As it should be clear to you by now, there are a multitude of benefits when you go with an online platform over physical stores. Some of the benefits are summarized below in a few key points:

Huge Variety And Selection

The online platforms around the world are growing exponentially in size, and that applies to the selection of products as well. As they get more popular, more and more brands sign up to sell their products on online platforms.

They have a wide range of products across many categories, divided and organized well. This helps you find exactly what you are looking for easily. You may even get software-generated recommendations for products you may need. This includes probiotics rhamnosus reuteri and many more.

Having a huge variety means that you can assess your preferences and choices. You can choose from a range of alternatives before purchasing. This is often not the case in most physical stores, where there is a limitation to the number of brands.

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Consistency Is Key As You Continue With Your Journey The Benefits Will Continue To Grow*

  • Within Hours

    Delayed-release capsule technology allows for more probiotics to pass through the acidic conditions of the stomach and reach the gut intact.*

  • Two Weeks

    Stick with the routine.* You need to stay consistent to give yourself optimal results.* Maximize your microbiome support by reducing sugar and caffeine intake as you continue your 1MD Nutrition® journey.*

  • Month 1

    The clinically-studied strains in UREX and Bifidobacterium lactis UABla-12 can help maintain yeast balance to promote the health of the vaginal microbiome.*

  • Month 3 and Beyond

    The Advanced Prebiotic Blend helps nourish the good bacteria in your body while the robust probiotics maintain a healthy balance in the digestive system, supporting a healthy vaginal pH level, urinary tract function, and immune health.*

*Individual results may vary. This timeline may not reflect the typical purchaser’s experience, and is not intended to represent or guarantee that anyone will achieve the same or similar results.

Summary Lactobacillus Rhamnosus Vs Lactobacillus Reuteri

Swanson Lactobacillus Rhamnosus Probiotic with Prebiotic Fos 5 Billion ...

Lactobacillus rhamnosus and Lactobacillus reuteri are two bacterial species belonging to the genus Lactobacillus. Both bacterial species are gram-positive, rod-shaped, and non spore-forming bacteria. Lactobacillus rhamnosus is a bacterial species that may sometimes be pathogenic in people who have weakened immunity and infants, while Lactobacillus reuteri is a bacterial species that are generally non-pathogenic. So, this is the summary of the difference between Lactobacillus rhamnosus and Lactobacillus reuteri.


2. Mu, Qinghui, et al. Role of Lactobacillus Reuteri in Human Health and Diseases. Frontiers in Microbiology, Frontiers Media S.A.

Image Courtesy:

1. Lactobacillus rhamnosus-LSU lab By Bsimon2014 This photo was taken under the supervision of an instructor at LSU. It was taken in the lab of Dr. Karen Sullivan via Commons Wikimedia

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How We Chose The Best Probiotic Supplements

We selected the best probiotics using the following criteria:

  • Vetting. All the products have been vetted to ensure that they meet Healthlines medical and business standards. You can read more about our vetting process here.
  • Effective dose. All of the supplements below contain at least 106 CFUs per gram.
  • Ingredients. We looked for products that are made from high quality ingredients and free of artificial additives and fillers.
  • Personal needs. Whether you need a specific probiotic strain or follow a gluten-free diet, we included options to suit a variety of needs and preferences.

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What Is Lactobacillus Rhamnosus

Lactobacillus rhamnosus is a bacterial species that belongs to genus Lactobacillus. Earlier it was considered to be a subspecies of Lactobacillus casei but recent genetic research concluded that it is a separate species in the L. casei clade. L. rhamnosus is a gram-positive, homofermentative, facultative anaerobic, rod-shaped, and non-spore-forming bacterial species. It often appears in a chain. Some strains of this species are used as probiotics. They are also useful in treating infections of the female urogenital tract such as bacterial vaginosis.

Figure 01: Lactobacillus Rhamnosus

The bacterial species Lactobacillus rhamnosus and Lactobacillus reuteri are commonly found in the healthy female genitourinary tract. They are helpful to control dysbiotic overgrowth of other bacteria during the infection period. This bacterial species is sometimes used in dairy products such as fermented milk and long ripened cheese. Though this species is considered to be beneficial, it may not be beneficial to some subsets of the population. This is because in rare circumstances, it causes endocarditis in those who have weakened immunity and infants. However, despite the rare infections caused by L. rhamnosus, it is included in the list of bacterial species with qualified presumed safety status of the European Food Safety Agency.

Potential Benefits Of The Lactobacillus Reuteri Probiotic

Making lactobacillus reuteri yoghurt recipe

Ana Aleksic, MSc Jonathan Ritter, PharmD, PhD Puya Yazdi, MDAna Aleksic, MSc

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The L Reuteri Probiotics I Recommend

Not all Lactobacillus reuteri probiotics are created equal. There are multiple different strains of Lactobacillus reuteri, which have different effects.

The precise strain that raised testosterone in the MIT rat study was Lactobacillus reuteri ATCC 6475. Other reuteri strains may or may not have the same effect it is impossible to say for sure before further studies are carried out.

ATCC 6475 is not the most common strain in probiotic supplements, but . A Swedish probiotic manufacturer called BioGaia actually owns the patent for ATCC 6475.

While I havent yet tested BioGaias probiotics myself, I plan to do so in the near future. I have taken another L. reuteri probiotic called Primadophilus on several occasions. It contains another well documented L. reuteri strain, and also carries Lactobacillus rhamnosus which had the positive effect on cortisol levels.

Probiotics are regarded as generally safe for most people. Nevertheless, there is always a risk of adverse effects with any supplement or dietary change. People who suffer from histamine intolerance or immunosuppression may have an increased risk of harmful side effects from probiotic intake.

Beneficial bacteria are also found in certain foods yogurt, sauerkraut, kombucha, kimchi and aged cheese all contain a high number of probiotic microbes.

Commensals Induce Subtle Changes In Cytokine Networks

The ability of Lactobacillus reuteri to metabolize tryptophan to indole-3-aldehyde, which activates the aryl hydrocarbon receptor on ILC to induce the barrier protective cytokine IL-22. Indeed, it is now clear that the Ahr is important in providing a docking site for microbiota derived ligands for activation of the immune system . Studies with probiotic strains of bacteria like E. coli Nissle have shown its ability to change the direction of immune responses from Th2 to Th1 protective immunity . In the last decade thymic stromal lymphopoietin has been shown to be induced by intestinal bacteria and is important for controlling inappropriate Th17 responses through the maturation of FOXP3 T-regulatory cells .

Kalpesh G. Patel, Nikolaos T. Pyrsopoulos, in, 2019

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