Innovixlabs Mood Probiotic 60 Capsules Lactobacillus Helveticus Rosell
- INNOVATION IN PROBIOTIC SCIENCE: InnovixLabs Mood Probiotic is a supplement containing a select group of probiotic bacteria that have been studied for their effect on mood and brain function. These bacteria are sometimes called psychobiotics.*
- CLINICALLY STUDIED FOR MOOD HEALTH: New research reveals a connection between gut health and mood. InnovixLabs Mood Probiotic is formulated with 2 unique clinically studied strains: Lactobacillus helveticus Rosell-52ND and Bifidobacterium longum Rosell-175.*
- CLINICAL RESEARCH: Research has shown that the unique probiotic blend used in InnovixLabs Mood Probiotic may help you cope better in stressful situations,* ease digestive discomfort associated with stress,* and support positive mood and emotional wellness.*
- TESTED FOR PURITY, POTENCY, AND FRESHNESS: InnovixLabs probiotic supplements are cultivated and encapsulated in Canada. They are tested and packaged in the USA. All batches are tested and verified by in-house and third-party labs for your peace of mind. Manufactured in a cGMP certified facility for safety and reliability.
- MADE WITHOUT: Mood Probiotic is made without eggs, corn, fish, shellfish, tree nuts, peanuts, wheat/gluten, sugar, GMOs, yeast, Chinese ingredients, and artificial colors or flavors. It may contain trace amounts of soy/milk used in the fermentation process.
Where To Find Lactobacillus Rhamnosus Gg
At the time of this writing, LGG is found in many products all over the world. Forexample, Aktifit® by Emmi Switzerlandis a yogurt drink containing LGG with Streptocucusthermophilus, although the amounts of each in a serving are unknown. Sincethere are so many products, the best advice is to always, always, read product labels.
In the USA, LGG isfound in at least 4 mainstream supplement products,
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Other Lesser Known Ppi Side Effects
PPIs interfere with the absorption of calcium, iron, zinc, and chromium to name a few. This means that you arent getting nutrients very well from the food you eat.
Stomach acid is also required for proper protein digestion as well. Think about it. You are trying to block acid, but the blocking of acid causes indigestion. Yikes.
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Lactobacillus Rhamnosus Gg And Cystic Fibrosis
Individuals with cystic fibrosis often display high levels of inflammation, mucus formation and microbial dysbiosis . There is potential for the use of probiotics, especially given their ability to reduce RTIs through the gut-lung axis. L. rhamnosus GG has been assessed in a few pilot studies in children with CF.
A controlled prospective study specifically assessed intestinal inflammation in 30 children with CF. A total of 75 children were included 30 with CF, 30 healthy controls and 15 with active inflammatory bowel disease. Ten of the children with CF received 5 billion L. rhamnosus GG daily for four weeks. After intervention faecal calprotectin levels significantly decreased in this group. These results highlight the potential of L. rhamnosus GG to reduce gut inflammation in CF patients . Reduced calprotectin levels were also found in a later trial using L. rhamnosus GG, the study also found distinct microbial changes in CF individuals .
Surprisingly a larger recent study in 2018, found L. rhamnosus GG did not have beneficial effects in children with CF. The RCT divided 95 children to receive either 6 billion CFU of L. rhamnosus GG or a placebo daily for 12 months. No differences in pulmonary exacerbations or hospital admissions were noted. The authors concluded that perhaps the trial was conducted under more stringent conditions or whether a childs age may play a role in L. rhamnosus GG efficacy .
Lactobacillus Rhamnosus Gg And Diarrhoea
Diarrhoea in children can lead to dehydration and severe complications. Despite this, there is little over the counter medication they can take to prevent diarrhoea or to manage early symptoms. L. rhamnosus GG has been found to alleviate diarrhoeal symptoms in both GI infections and antibiotic associated diarrhoea .
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Lactobacillus Rhamnosus: Health Benefits And Possible Side Effects
Lactobacillus rhamnosus is one of the most common bacteria found in the body. It helps to produce lactase, which breaks down lactose sugars into lactic acid. Read on to learn more about its benefits.
12 minute read
The body contains trillions of bacteria, most of which are beneficial to your health, including Lactobacillus rhamnosus, or L. rhamnosus. In fact, this is one of the most common bacteria found living in the human body.
As part of the lactobacillus genus, this bacterium produces the enzyme lactase, which breaks down lactose sugars into lactic acid. Lactic acid is beneficial for maintaining a healthy microbiome and supporting gut health and proper nutrient absorption. Lactic acid also promotes antioxidant capacity to support the health of all tissues in the body.
L. rhamnosus has adapted in a way that allows it to resist stomach acid, to travel safely to the intestinal tract. Here, it is able to colonize your digestive tract to help protect against common environmental threats.
L. rhamnosus has a great affinity for intestinal mucosal cells, which allows it to colonize and thrive within the human gut. There are a variety of L. rhamnosus strains, each with its own strain-specific gene functions, allowing it to adapt to a wide range of environments.
Exopolysaccharides As Modulating Adaptation Factors
An extracellular polysaccharide layer is commonly found in lactobacilli. Of interest, EPS molecules show a large structural diversity , so that they are clearly strain-specific molecules. The LGG cell surface appears to contain two major types of polysaccharides: long galactose-rich polysaccharides and shorter glucose/mannose-rich polysaccharides . We could yet identify the operon responsible for galactose-rich EPS synthesis . A knock-out mutant of the welE gene, encoding the priming glycosyltransferase, is completely devoid of the long galactose-rich EPS but shows a higher concentration of short glucose-rich EPS . This mutant shows an increased adhesion to Caco-2 IECs, linked to increased exposure of the SpaCBA pili . In addition, this type of galactose-rich EPS appears to be an important adaptation factor for LGG as the welE mutant shows a reduced in vivo survival in the murine gastrointestinal tract . More specifically, the long galactose-rich EPS were shown to protect the cell against complement-mediated lysis and cathelicidins, specific cationic antimicrobial peptides . It thus seems important that this type of EPS production is balanced between optimal protection and optimal adhesion.
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Probiotics For Gastrointestinal Conditions: A Summary Of The Evidence
THAD WILKINS, MD, MBA, Medical College of Georgia at Augusta University, Augusta, Georgia
JACQUELINE SEQUOIA, MD, MPH, William Jennings Bryan Dorn VA Medical Center, Columbia, South Carolina
Am Fam Physician. 2017 Aug 1 96:170-178.
Patient information: See related handout on probiotics, written by the authors of this article.
Probiotics contain microorganisms, most of which are bacteria similar to the beneficial bacteria that occur naturally in the human gut. They are available over-the-counter or by prescription and in a variety of forms such as capsules, packets, or food supplements. Although most probiotics are available without a prescription, there may be an advantage to patients with prescription drug coverage because probiotics may be a covered benefit. Probiotics have been widely studied in a variety of gastrointestinal diseases, and one in five Americans takes probiotics for digestive problems.1 The most studied probiotics for human use belong to the Lactobacillus, Bifidobacterium, or Saccharomyces species.2 This article focuses on probiotic use in infants, children, and adults with GI conditions, and it excludes probiotics for non-GI diseases.
The Benefits Of Lactobacillus Rhamnosus
Studies involving the Lactobacillus strain of bacteria suggest supplementation could lessen feelings of anxiety or ease symptoms of depression. Combining these probiotics with prebiotics also show significant benefits in mood health. One study suggests taking L. rhamnosus might counteract weight gain and diabetes, and theres a lot of research examining the benefits as a treatment for gastrointestinal issues like irritable bowel syndrome. Another study suggests a link between good bacteria and seasonal allergies, particularly with hay fever.
Now, one cool thing about L. rhamnosus is that it can stay happy in rough conditions. Anyone who has ever had acid reflux knows how stomach acid can cause discomfort. Well, this probiotic strain actually thrives in an acidic stomach. If youre looking for something to strengthen your overall immune function, L. rhamnosus could help there. A promising study suggests this strain could be just as helpful as an antibiotic for treating urinary tract infections.
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Not My Favorite Probiotic Brands
These brands either didnt contain any bacterial strains that were closely linked with health impacts we set forth above OR they did not tell us what bacterial strains they were using at all. This is important for transparency, safety, and effectiveness. Brands in this area may also contain additives and junk we just dont want in our probiotics.
- Advocare ProBiotic RESTORE ULTRA
- Visbiome Extra Strength High Potency Probiotic
Study Eligibility For Efficacy
Inclusion criteria for articles assessing probiotic efficacy included: randomized controlled trials of a probiotic intervention , in adults or children, reported duration of intervention and/or follow-up, for either prevention or treatment of disease and peer-reviewed publication . We included RCTs with primary outcomes of either prevention or treatment of various diseases and, if present, secondary outcomes and additional treatment arms in this review. As the efficacy of probiotics is both strain-specific and disease-specific , each type of probiotic was required to have at least two RCTs for each disease indication being considered. The probiotic intervention was required to be well defined by strain or strains if a mixture of species were used and the daily dose. Exclusion criteria for efficacy assessments included: reviews, kinetic or safety studies, non-randomized trials, duplicate reports, and trials with insufficient descriptions of the type of probiotic. Probiotic products with less than two RCTs per disease indication were excluded. Disease indications with less than two RCTs per probiotic type were also excluded. Pre-clinical studies of mechanisms of action or safety studies were also excluded from the efficacy assessments.
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What Is Acid Reflux
According to the World Gastroenterology Organization, gastroesophageal reflux disease is troublesome symptoms sufficient to impair an individuals quality of life or injury or complications that result from the retrograde flow of gastric contents into the esophagus, oropharynx, and/or respiratory tract .
In contrast, acid reflux can occur occasionally and isnt as serious as GERD most people experience acid reflux symptoms at least a few times a year due to lifestyle factors.
Acid reflux symptoms include:
- Need to clear the throat frequently
- Ulcers and bleeding
GERD can be serious and should be evaluated by your doctor or healthcare practitioner.
However, there are some important lifestyle habits that can naturally reduce acid reflux symptoms. And the fact is, reflux isnt always caused by too much stomach acid and common medications like proton pump inhibitors may not be needed.
It can be caused by many factors other than too much stomach acid.
Just so you know, functional dyspepsia and acid reflux are often one in the same thing as far as symptoms go.
Peptiva 26 Billion Cfu Probiotic And Sleep Support
- Formulated with ultra-potent ingredients, Peptiva + Sleep Support optimizes healthy digestion while providing reliable relief from occasional intestinal discomfort
- This powerful, daily probiotic supplement for men and women includes a clinically validated multi-strain probiotic matrix thats been shown to provide maximum support to help renew digestive health
- These doctor-formulated probiotics for men and woman have been shown to help promote intestinal comfort, function and regularity. Plus, it helps you feel more relaxed in about 30 minutes
- Dr. David Katz the director and co-founder of the Yale Prevention Research Center formulated this groundbreaking probiotic supplement to support healthy digestion and promote relaxation & sleep
- Probiotics are good for men and woman looking to restore digestive health or alleviate nagging digestive issues. When taken daily, youll experience maximum benefits starting in 12 weeks
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Medical Research And Use
While L. rhamnosus GG is able to survive the acid and bile of the stomach and intestine, is claimed to colonize the digestive tract, and to balance intestinal microbiota, evidence suggests that L. rhamnosus, comparable to virtually all probiotic lactobacilli, is only a transient inhabitant and not autochthonous. Regardless, it is considered a probiotic useful for the treatment of various maladies, as it works on many levels. Lactobacillus rhamnosus GG binds to the gut mucosa.
Diarrhea
Lacticaseibacillus rhamnosus GG is beneficial in the prevention of rotavirusdiarrhea in children. Prevention and treatment of various types of diarrhea have been shown in children and in adults.L. rhamnosus GG can be beneficial in the prevention of antibiotic-associated diarrhea and nosocomial diarrhea and this has been recently supported by European guidelines.Lactobacillus rhamnosus GG may reduce the risk of traveler’s diarrhea.
Acute gastroenteritis
A position paper published by ESPGHAN Working Group for Probiotics and Prebiotics based on a systematic review and randomized controlled trials suggested that L. rhamnosus GG may be considered in the management of children with acute gastroenteritis in addition to rehydration therapy.
Atopic dermatitis, eczema
Risks
What Causes Acid Reflux
Acid reflux or heartburn, is really common, but not for the reasons many people think.
According to the National Institute of Diabetes and Digestive and Kidney Diseases , about 1 in 5 people have this frustrating condition of GERD, while even more people have occasional acid reflux or heartburn .
These conditions can be caused by hiatal hernia, medications like Ibuprofen, and genes, but there is definitely more to the story for most people.
Its tempting to blame heartburn and acid reflux on genes, but the truth is, the reason GERD is so common now is that it often boils down to foods that you are eating or stress .
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Diversity Of Available Probiotic Products
The first challenge in choosing an appropriate probiotic is the diversity of products available from which to choose and the lack of guidance on which products may be more effective. Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host . However, the burden of proof for health benefits varies by country. We found a variety of types of probiotic products available on the market as prescription products, as over-the-counter products, or as dietary supplements. In the U.S.A., probiotics currently are available as dietary supplements, which are only allowed generalized health claims that relate to host structure or function. Twenty-five types of probiotic products commonly found as over-the-counter dietary supplements or on-line are shown in . Unfortunately, the health claims on the labels of dietary supplements often do not provide practical clinical guidance for healthcare providers nor for the general public. Several probiotic products are being developed as potential drugs under the F.D.A. regulated pathway, but none have been approved currently as prescription products. Probiotics have a long history of use in Europe and Asia, but in 2013, the use of probiotic was disallowed on the label due to the disparity of evidence for various claims for health benefits . Currently, regulations relating to probiotics are in flux and differ dramatically from country to country.
Antistress Effects Of Probiotics
Barreau et al. have reported that probiotic treatment consisting of Lactobacillus rhamnosus and Lactobacillus helveticus can ameliorate enhanced basal HPA axis activity induced by maternal separation stress in rats, suggesting that probiotics normalize the activity of the HPA axis. The same treatment with probiotics also ameliorated water avoidance stress-induced elevations in serum corticosterone levels compared with placebo . In line with these observations, Bravo et al. showed that the levels of stress-induced corticosterone are significantly lower in stressed mice fed L. rhamnosus compared with their control broth-fed counterparts. Thus these findings support the notion that probiotics exert a protective effect on stressed hosts.
Michael T. Murray ND, John Nowicki ND, in, 2020
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Secreted Proteins As Probiotic Effectors
In 2002, Yan and Polk showed that LGG promotes the survival of intestinal epithelial cells by preventing cytokine-induced apoptosis through blocking of p38 MAP kinase. They found that the survival-promoting effect was also present in other probiotic strains such as L. acidophilus ATCC393 and L. casei ATCC4356, but the strongest in LGG . The supernatant of LGG was shown to prevent apoptosis in IECs and induce heat shock proteins . Consequently, two proteins from the LGG supernatans were found to cause the antiapoptic effect . These proteins p75 and p40 were later renamed as Major Secreted Protein Msp1 and Msp2 respectively, because of the discrepancy in molecular weight . Each of the purified proteins was shown to activate the Akt signaling peptide, inhibit cytokine-induced IEC apoptosis and reduce tumor necrosis factor – induced epithelial damage. The proteins also promoted cell growth in human and mouse colon IECs and cultured mouse colon explants . Moreover, they were shown to protect the intestinal epithelial barrier function from hydrogen peroxide-induced damage through blocking of MAP kinases .
Lactobacillus Rhamnosus Gg Side Effects
Get emergency medical help if you have signs of an allergic reaction:hives difficulty breathing swelling of your face, lips, tongue, or throat.
Although not all side effects are known, lactobacillus rhamnosus GG is thought to be likely safe for most people when used as directed.
Common side effects of lactobacillus rhamnosus GG may include:
-
stomach bloating or gas.
This is not a complete list of side effects and others may occur. Call your doctor, pharmacist, herbalist, or other healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Lactobacillus Rhamnosus Gg Dosing Information
Usual Adult Dose for Dietary Supplement:
For general use as a dietary supplementDose: 1 capsule per dayConcurrently with antibioticsDose: 1 capsule twice a day throughout antibiotic therapy and for one week after antibiotic therapyTravelingDose: 1 capsule twice daily throughout the tripIt is best to start 2 to 3 days prior to travel.
Usual Pediatric Dose for Dietary Supplement:
Dose: One-half to one capsule per day.Open the capsule and stir the contents into a cool drink or mix into baby food or applesauce.
