Tuesday, May 28, 2024

Which Probiotics Make It To The Gut

Comparative Analysis Of The Effect Of Glucose On Survival Of Probiotic Lactobacilli

Probiotics Benefits Myths | Improve Gut Health | Doctor Mike

In order to analyze whether glucose enhances survival of other probiotic or intestinal lactobacilli in a simulated gastric environment, stationary-phase cultures were assayed for survival in a single-time analysis following exposure for 45 min .1). The results showed that the greatest survival effect attributable to glucose occurred in L. rhamnosus GG cultures, while L. gasseri ATCC 33323 did not require the presence of glucose at pH 2.0 for optimal survival. The results therefore indicated that L. gasseri ATCC 33323 was the most intrinsically acid-resistant strain studied, as it had the best survival in the absence of glucose at pH 2.0 . However, when the pH of simulated gastric juice was reduced to 1.75, an enhanced survival effect in L. gasseri ATCC 33323 cultures grown in the presence of glucose was clearly observed , although the concentration was approximately 2.7 log10 CFU ml1 lower than the concentration of L. rhamnosus GG. Similarly, when the pH was increased to 2.25, an enhanced protective effect of glucose on L. paracasei NFBC 338 was observed .

Probiotic Foods To Help Balance Your Gut

Itâs true that probiotics can be found in some foods. You might already include them in your diet, or you may be able to replace a food currently in your diet with another that specifically contains probiotics. But picking a probiotic food is not as easy as picking any yogurt off the shelves at the store, and not all fermented foods have probiotics in them.

Finding foods with live cultures is easy. Finding foods with live cultures that have proven health benefits requires attention to detail and research. Plus, you need to make sure youâre getting enough probiotics from those foods in your diet to actually get the health benefit you want.

Yogurt is a classic example. All yogurts do contain live cultures at some point as they are being made. However, as a part of the manufacturing process, the live cultures donât always survive until the yogurt makes it to store shelves. Alternatively, some yogurts still contain live cultures post-processing, however, the specific strains used to make the yogurt provide no benefits to humans.

The truth is, few yogurts naturally contain a probiotic strain. Oftentimes, probiotics are added to the yogurt, but not used as part of the production process.

If you donât already eat fermented foods, there are other options to help you add probiotics to your gut without making a significant dietary change. Probiotic supplements like Align DualBiotic Prebiotic + Probiotic Gummies will guarantee you add more good bacteria to your gut.*

When Ingesting Probiotics Does Anything Live Survive Stomach Acids To Populate Small Or Large Intestine

Sarah Comstock from the MSU Department of Food Science and Human Nutrition explains what probiotics are and how they work.

First, let’s define probiotic. The precise definition of probiotics is the subject of ongoing discussions. For the purposes of the guidelines, probiotics are defined in accordance with the Food and Agriculture Organization of the United Nations and World Health Organization definition: live microorganisms which when administered in adequate amounts confer a health benefit on the host.

The short answer, is, yes, some probiotic bacteria are still alive when they reach the small intestine and even the large intestine, but they dont populate those environments. Probiotic bacteria can only transiently populate the intestine. This means that if you stop taking the probiotic, you will no longer have that bacteria in your intestines.

For more information, check out “Are Probiotics Useful for the Average Consumer?” and “Fate, activity, and impact of ingested bacteria within the human gut microbiota.”

Reference: Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria. . Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria.

Sarah S. Comstock, Ph.D., is an assistant professor in the Department of Food Science and Human Nutrition at Michigan State University.

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Side Effects Of Probiotics

Most healthy people can take probiotics in both food and supplement form safely, without noticing any side effects. You should always check the label and talk to a pharmacist or doctor before taking supplements if youre pregnant or breastfeeding.

In rare cases, you might notice a reaction in the first few days, but this will usually go away on its own. Symptoms may include:

  • an upset tummy
  • bloating
  • gas

In certain people, taking probiotic supplements might cause infection. This could be the case if you have:

  • a weakened immune system
  • a critical illness
  • recently had surgery

You should speak to a doctor before considering probiotics if this is the case. Read more about whether probiotics are safe for everyone.

Best Probiotic Supplements For Gut Health In 2021

Genuine Health

This article was produced in partnership with Blue Ribbon Group

Due to the pandemic, people have mostly stayed indoors. As a result, keeping a well-nourished and healthy body has become challenging even for those who actively go to the gym or exercise regularly.

However, along with the efficient & best probiotics, one can still attain an immunized body and good health to push through the boundaries these rough times have given us.

With a combination of safe and beneficial bacteria, probiotics help optimize your immune system. They aid in fighting damaging bacteria and assist tissues and cells through their vital repair process. Probiotics can also help good bacteria with their natural selection and get rid of unwanted microbes that toxify our blood.

Now more than ever is the time to take care of ourselves and be healthy through proper diet and exercise. So, make sure to consume the right probiotics that will ensure sustainable immunity and everyday health.

In this article, we have provided the best and most trustworthy probiotics available and have described how each can help you achieve good health.

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The Glycolytic Inhibitor Iodoacetic Acid Eliminates The Glucose Effect

In order to further study the ability of the glycolytic system to provide ATP to cultures of L. rhamnosus GG, we used iodoacetic acid, which has previously been used to specifically inhibit GAPDH, a key enzyme in the glycolytic pathway . The results showed that addition of IAA to cultures prior to analysis reduced viability by 8.30 log10 CFU ml1 in simulated gastric juice, pH 2.0, with glucose .4). Interestingly, the rate of decline of cultures containing IAA was similar to that of L. rhamnosus GG in simulated gastric juice without glucose .2b). Therefore, the data imply that glucose protected L. rhamnosus GG by glycolysis for provision of ATP for homeostasis. We also determined that the concentration of IAA used was not toxic to cells at neutral pH, as determined by viable cell counts, and that this concentration was sufficient to reduce the growth rate of L. rhamnosus GG . In addition, we observed that L. rhamnosus GG grew only slightly slower in the presence of IAA .

Survival of stationary-phase L. rhamnosus GG cultures in simulated gastric juice, pH 2.0, containing glucose , glucose and IAA , no glucose , or no glucose and IAA .

Probiotics May Help Boost Mood And Cognitive Function

Probiotics can do more than improve your gut health. They also may indirectly enhance your brain, too.

Research shows that the gut and brain are connected, a partnership called the gut-brain axis. The two are linked through biochemical signaling between the nervous system in the digestive tract, called the enteric nervous system, and the central nervous system, which includes the brain. The primary information connection between the brain and gut is the vagus nerve, the longest nerve in the body.

The gut has been called a “second brain” because it produces many of the same neurotransmitters as the brain does, like serotonin, dopamine, and gamma-aminobutyric acid, all of which play a key role in regulating mood. In fact, it is estimated that 90% of serotonin is made in the digestive tract.

What affects the gut often affects the brain and vice versa. When your brain senses troublethe fight-or-flight responseit sends warning signals to the gut, which is why stressful events can cause digestive problems like a nervous or upset stomach. On the flip side, flares of gastrointestinal issues like irritable bowel syndrome , Crohn’s disease, or chronic constipation may trigger anxiety or depression.

It’s too early to determine the exact role probiotics play in the gut-brain axis since this research is still ongoing. Probiotics may not only support a healthier gut, but a healthier brain, too.

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When Is The Best Time To Take Probiotics In A Supplement

Probiotic supplements are the easiest and most effective way of boosting your beneficial bacteria and optimizing your gut health.

And just like with probiotic-boosting foods, the timing of when you take probiotic supplements is crucial in maximizing their efficacy and positive benefits.

High-quality probiotic supplements give optimal results with your biggest meal.

If you follow a more American dietary structure, that means youll probably be taking a probiotic capsule with dinner. But if you eat your biggest meal at midday, like many Mediterranean or Caribbean countries, then you should take your probiotics at lunchtime.

Comparative Survival Of Probiotic Lactobacilli In A Simulated Gastric Environment

Best 3 Probiotics for Gut Health and IBS and HOW TO CHOOSE

Cultures of L. rhamnosus E800, L. rhamnosus GG, L. salivarius UCC 500, L. paracasei NFBC 338, and L. gasseri ATCC 33323 were grown overnight in 25 ml MRS medium and subcultured by using 1% inocula. The cultures were subsequently centrifuged at 7,000 ×g at 4°C for 15 min, washed once in an equal volume of cold 0.25× Ringer’s solution, and subsequently centrifuged . Pellets were then resuspended in an equal volume of simulated gastric juice at 37°C and incubated for 90 min with constant stirring. Samples were taken at 0, 10, 30, 60, and 90 min, serially diluted in maximum-recovery diluent, plated on MRS medium, and incubated at 37°C for 72 h.

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How Fermentation Creates Probiotics

For centuries, people have used fermentation to process food, transforming one type of food into another: cucumbers become pickles, milk becomes yogurt, soybeans become miso

As it turns out, fermentation doesnt just preserve food. It also optimizes the foods health potential with beneficial bacteria.

During fermentation, naturally-occurring bacteria feed on the sugar and starch in the food, creating acid as a byproduct. This generates an environment that supports the growth of enzymes, B vitamins, omega-3 fatty acids, and of course, beneficial bacteria. For example:

Lactic Acid Bacteria

Fermentation is sometimes referred to as lacto-fermentation, because the most commonly produced acid is lactic acid. And as a result, the probiotic most often found in fermented foods is lactic acid bacteria or Lactobacillusthe same beneficial bacteria often advertised on probiotic yogurts, for example.

Acetic Acid Bacteria

Fermentation will sometimes produce acetic acid instead, which is associated with the development of vinegars. Kombucha and apple cider vinegar both produce acetic acid as part of their fermentation process. The beneficial bacteria created as a result is Acetobacter, also known as acetic acid bacteria.


  • Tempeh
  • Yogurt

Fermentation changes a foods scent and flavor quite a bit. In general, they are a bit stronger and may take some getting used to. Not everyone is going to be a fan of pickles from the first bite!

Can Probiotics Help Stress Anxiety And Mood

Certain probiotic strains appear to have a calming effect on our emotions. Friendly bacteria strains are sometimes referred to as psychobiotics. Scientists are investing a lot of effort to figure out how various probiotic strains affect our mental health. Our gut microbiota is thought to influence our mood in three ways at the moment, however, more studies may find other mechanisms of action in the future.

1. To start, certain probiotics, such as GABA , serotonin, and dopamine, can create neurotransmitters in the gut or influence the bodys ability to produce neurotransmitters. Neurotransmitters are chemical messengers that carry information throughout our nervous system.

These compounds are released in the gut and affect nerve cell signalling, which influences the information sent to our brain. This has a direct impact on our brain chemistry and function, influencing our behaviour and mood as a result.

Because it improves our mood, serotonin is commonly referred to as our happy or feel good neurotransmitter. As a means of combating depression, certain pharmaceutical anti-depressants target serotonin signalling in the brain.

When beneficial probiotic bacteria in a healthy gut microbiome break down prebiotic fibres, they create short-chain fatty acids . These SCFAs can help keep the gut lining in good shape, reducing inflammation caused by increased intestinal permeability.

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Complications Of Chronic Liver Disease/hepatic Encephalopathy

Luminal microbiota play an important role in the pathogenesis of both spontaneous bacterial peritonitis and hepatic encephalopathy. Ammonia produced by gut bacteria is believed to play a key role in hepatic encephalopathy. Antibiotics are employed in clinical practice to reduce severity or frequency of both these chronic liver disease complications. Lactulose, a mainstay of therapy, is a prebiotic for lactobacilli which can limit bacterial ureases.

The role for probiotics in these disorders is an area of ongoing investigation. Treatment of hepatic encephalopathy with lactobacillus acidophilus was studied as early as 1965. More recently, Liu and colleagues offered a probiotic and prebiotic mixture to 97 patients with minimal hepatic encephalopathy and observed a reduction in ammonia levels and improvement in encephalopathy. Another group found that a yogurt-based probiotic supplement significantly improved quantitative measurements of minimal hepatic encephalopathy in nonalcoholic cirrhotics. The latter group is now completing a more comprehensive trial using the probiotic LGG in a similar patient cohort.

Society guidelines and expert consensus panels do not currently support a recommendation of probiotic use for any chronic liver disease associated condition.

Do Probiotics Survive Stomach Acid

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If you are reading this, then the chances are that you have some concerns about whether or not the probiotics you are taking, or thinking of taking, survive to reach the gut alive. You may be confused as to whether spending money on probiotics is indeed an investment in your own good health, or if it is a waste of money. I’d say that this common concern about survival through stomach acidity is a very valid one, but if you read on, I hope to put your mind at rest that there are some effective, well tested and researched probiotic supplements available on the market. Learn more about how to identify high quality probiotic supplements by reading the article: Researching probiotics online – how to identify quality content.

In part, the concern over the survival of probiotics through the stomach has been perpetuated by one small study1 performed at University College London back in 2014, which tested 8 probiotic products and found that only one of the probiotics tested survived gut acidity and then flourished in the intestines. We reported on this study at the time, and our response to this study on probiotics can be read on the Probiotic Professionals site. It is important to state that no Optibac Probiotics products were included in this study, and we are very confident that if they had been, the results would have shown that our strains show excellent survivability in most acid conditions.

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Probiotic Colonization Of The Intestinal Mucosa

Successful colonization of the gastrointestinal tract is a key factor for probiotics to be able to exert a sufficient host-interaction to confer health benefits . Mucosal adhesion is considered a critical step in probiotic colonization however, the mechanisms of adhesion still require exploring. In this section, we discuss the composition of the intestinal mucus layer and specific proteins related to probiotic adhesion.

Good For Your Mood And Mental Health

Research has uncovered a definite link between gut health and mental health. Thats not to say all mental disorders stem from poor gut health, but it does highlight the importance of what has been called the gut-brain axis.

This provides the background on why probiotics are proving to be helpful for some symptoms of mental disorders, including depression.

One recent study found that supplementing with probiotics for 8 weeks significantly reduced depression symptoms in participants. Interestingly, they also found that blood levels of glutathione increased with probiotic use, which could indicate that antioxidants may play a role in easing depression.

Other research also indicates improvement of symptoms with probiotic supplementation in other disorders like anxiety, obsessive-compulsive disorder, and autism spectrum disorder.

Again, there is much more research to be done on probiotics and their connection to the brain, but they certainly deserve to be considered as part of a comprehensive treatment for mental health issues.

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Top Recommendation: Just Thrive Probiotic

If you are in the market for a top quality probiotic supplement, Just Thrive Probiotic is one that I personally use after extensive research. Just Thrive is a highly effective choice that overcomes the problems many other probiotics have.

One of the big challenges with probiotics is getting them to your intestines where they actually do their work. Most supplements start out with a high probiotic amount, but over 90% of the strains can get killed off in stomach acid! Yes, this includes most options that need to be refrigerated .

To overcome this problem, Just Thrive Probiotic uses unique and natural spore-based delivery.

The four clinically-proven, super probiotic strains essentially go dormant as they pass through the harsh environment of your stomach. Then, they wake up at your small intestine and start forming colonies of beneficial bacteria.

The results of this new probiotic technology are incredible and noticeable- unlike other probiotics that dont seem to do anything.

Garden Of Life Colon Daily Care 40 Billion Cfu

Gut Tested Probiotics Before & After! @The Gut Warâ

This well-known brand of probiotic boasts 40 Billion CFU per capsule with 16 strains of probiotic bacteria. This includes B. lactis HN019, a strain proven to help promote bowel regularity and help relieve bloating. It also has the nice feature of a desiccant-lined bottle technology to support the shelf life of the probiotics, and its allergen-free.

The only concern with this probiotic is that it does not use an effective method to deliver its bacteria past stomach acid, so its hard to say whether those 40 billion probiotic bacteria are guaranteed to reach the intestines.

Check out Garden of Life Colon Daily Care 40 Billion CFU here.

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