Monday, May 27, 2024

Best Probiotic Strain For Rheumatoid Arthritis

Our Comprehensive Probiotics Guide

Today’s HealthNews For You Probiotics and Arthritis

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Brain Fog And Cognitive Function

Data here are preliminary but encouraging. Research has found increased brain fog, aka lack of coherence, in those with IBS. We have discussed the impressive evidence substantiating probiotics can improve IBS. So, we can draw a tenable inference here that if IBS occurs with brain fog, reducing IBS could reduce brain fog.

Proof

A 2020 Meta-analysis looked at 7 human and 11 animal studies. Researchers concluded that probiotics enhanced cognitive function. Effects of probiotics on cognitively impaired individuals were greater than those on healthy ones.

Brain fog, or fuzzy thinking, isnt usually studied in isolation but we can look at other disease-model studies where probiotics have improved cognition. This includes probiotics improving cognitive function in:

  • Fibromyalgia

Specific Strains Of Bacteria That May Affect Ra

Research has previously shown a link between RA and the bug Prevotella copri. A study published in the journal eLife found that the intestines of 75 percent of people with early, untreated rheumatoid arthritis had this bacterium in their intestines compared with 12 percent of people with chronic, treated rheumatoid arthritis. The theory is that this bacteria crowds out beneficial microbiota that fight inflammation or itself promotes inflammation.

Another study, published in April 2017 in Arthritis & Rheumatology, examined whether the overexpansion of Prevotella copri in the gut has the potential to affect immune cell functions, contributing to the development of RA. Study authors found that there is evidence for immune relevance of P. copri in RA. At this point, experts cant claim that P. copri causes RA, but the research provides an intriguing path for future study, according to an article published in November 2019 in the Journal of Clinical Medicine.

A different strain of the bacteria, Prevotella histicola, may actually decrease symptoms and disease progression, according to research done by Mayo Clinics Center for Individualized Medicine, published in April 2016 in Genome Medicine. Mice who were given the bacteria saw a delay in the disease and a reduction in the amount of cytokines in their system.

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A Special Dietary Starch Modulates L Reuteri Growth And Improves Autoimmune Symptoms

To assess the role of diet in modulating bacteria in lupus-prone mice, the team fed them food enriched with resistant starch, a type of fiber that resists digestion and is fermented by gut bacteria.

Resistant starch L. reuteri found in the feces and in the gut of mice fed with resistant starch. Resistant starch also tightened the gut epithelial barrier and reduced gut leakiness and L. reuteri translocation to the blood. Over time, resistant starch reduced lupus-related mortality and decreased the levels of inflammatory molecules in the spleen and gut.

The researchers discovered that L. reuteri growth was inhibited by short-chain fatty acids, in particular butyrate, which are the main metabolites of resistant starch fermentation by the gut microbiota.

In conclusion, these data suggest that a dietary intervention is sufficient to prevent the development of lupus-like disease, whose symptoms are exacerbated by the commensal L. reuteri strain. The findings could inform clinical approaches to restrain bacteria that contribute to autoimmune diseases.

Probiotics Are Safe And Beneficial For Infants & Mom

3 Best Probiotics For Rheumatoid Arthritis

The first thing we should ask here is, are probiotics safe for infants? Answer: yes and well elaborate below. Second question, do probiotics provide benefit to infants? Answer, again yes. That said, make sure to speak with your pediatrician before using a probiotic with your infant or child.

Probiotics are safe for healthy infants according to a systematic research review based on studies using six different probiotics . None of the studies found any safety concerns or adverse effects. Researchers found some benefits from probiotic use, including:

  • less colic and irritability,
  • fewer spitting episodes and
  • fewer respiratory infections.

Different benefits are connected with different strains, which suggests that a multi-strain formula may be the best choice.

Another systematic review with meta-analysis looked at 44 studies involving premature babies. Probiotics helped to prevent serious GI illnesses that are sometimes fatal for very low birth weight babies.

A very interesting review looked at the impact of prenatal and postnatal probiotic use. Researchers found several benefits for both mom and baby. Women who took probiotics during pregnancy had fewer incidences of:

  • Gestational diabetes
  • Pre-eclampsia
  • Excessive weight gain
  • Vaginal bacteria infections

Both studies noted that the babies born to these moms had much lower rates of eczema at birth and later in childhood.

More studies show that probiotics:

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Best Strains To Help With Rheumatoid Arthritis Symptoms

Rheumatoid arthritis is a chronic autoimmune disease that occurs when the immune system attacks normal tissue in the body, causing inflamed, swollen, and painful joints. Doctors promote anti-rheumatic drugs, steroids, non-steroidal anti-inflammatory drugs, physical therapy, and surgery as traditional treatments for rheumatoid arthritis.

Recent studies have found that some of the compounds in certain strains of the cannabis plant can help manage the symptoms of rheumatoid arthritis.

Probiotic Supplementation For Rheumatoid Arthritis: A Promising Adjuvant Therapy In The Gut Microbiome Era

  • 1Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
  • 2Serviço de Reumatologia e Doenças Ósseas Metabólicas, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa , Lisboa, Portugal
  • 3Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, CAML, Lisboa, Portugal
  • 4Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

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Probiotics Might Work Better If You Have Bacterial Overgrowth

Another exciting study found that probiotics work better for digestive symptoms if you also have SIBO , as compared to those who have digestive symptoms without SIBO.

  • Patients with both IBS and SIBO showed a 71.3% reduction in their total IBS score
  • IBS patients without SIBO only showed a 10.6% reduction

In this case a combination of Category 1 and Category 2 probiotics were used.

So, probiotics can improve digestive symptoms, combat SIBO and may work better if you have symptoms and SIBO.

Inhibition Of Expression Of Pro

Rheumatoid Arthritis Naturally: Probiotic: Coconut Milk Kefir

Cytokines play critical roles in the pathogenesis of RA, while inhibiting expression or function of cytokines increases the probability of remission of RA and protects bones from destruction . Therefore, we determined the serum levels of interferon- , tumor necrosis factor- , and interleukins -1, IL-17, IL-2, and IL-6 and determined the correlations between the levels of pro-inflammatory cytokines and alterations in the gut microbiota after L. casei treatment in AIA rats. The results showed a significant reduction in the levels of pro-inflammatory cytokines IFN-, TNF-, IL-1, IL-17, and IL-6 in the L. casei-treated AIA rats compared to the vehicle-treated AIA rats . In addition, the levels of IL-17 and IL-1, which are produced by activated adaptive and innate immune cells , respectively, were significantly reduced in the animals treated with L. casei. Collectively, these data indicate that the alleviation of arthritis in the L. casei-treated rats was related to the suppression of pro-inflammatory cytokine expression.

Fig. 4

L. casei inhibits pro-inflammatory cytokines expression via resurrection of L. acidophilus. a The expressions of cytokines in serum are assessed using ELISA. Data are shown as mean ± s.e.m and min, max. Differences between groups are analyzed by one-way ANOVA. . b Associations of the abundance of L. acidophilus with plasmatic cytokines. cc, Spearmans correlation coefficient after adjustment for weight, group, and arthritis score

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Can Your Gut Heal Your Joints

One of the hottest questions right now is whether it will be possible to treat arthritis and other diseases by adjusting the microbiome. A growing number of scientists think so.

Writing in a review article published in the March 2016 issue of Current Opinion in Rheumatology, researchers from the University of Glasgow in the UK noted that interventions targeting the microbiota may become therapeutically viable for some types of inflammatory arthritis.

That idea is echoed by Martin Blaser, MD, a microbiologist at New York University Langone Medical Center and a widely respected microbiome expert.

This is a fertile area for research because we know that particular microbes talk to human physiology in different ways with different vocabularies. As our understanding of this relationship grows, we may use it to regulate disease, he says.

Although there are few human studies, animal models have demonstrated some intriguing findings. A 2013 study published in the Journal of Interferon & Cytokine Research looked at the effect of two common bacterial strains on arthritis in rats. Results showed that bacteria commonly found in yogurt, Lactobacillus casei and Lactobacillus acidophilus, reduced joint inflammation more effectively than the NSAID indomethacin.

Both Dr. Scher and Dr. Blaser are optimistic about the future of microbiome research. These are very early days, Dr. Blaser says, but the field is moving ahead. This is the scientific frontier.

Who Should Not Use Probiotics

The National Institute of Health states that probiotics are generally safe, even for premature infants.

Given the large quantities of probiotics consumed around the world, the numbers of opportunistic infections that result from currently marketed probiotics are negligible. For example, probiotics have been administered to thousands of newborn infants, including some who were premature, without a single case of sepsis.

When not to use a probiotic

Those who are critically ill.

The journal Expert Opinions on Drug Safety recommends the following

Critically ill patients in intensive care units, critically sick infants, postoperative and hospitalized patients and patients with immune-compromised complexity were the most at-risk populations.

While the overwhelming existing evidence suggests that probiotics are safe, complete consideration of risk-benefit ratio before prescribing is recommended.

However, when it comes to immune-compromised individuals, recent research suggests that probiotics may be safe and beneficial. An analysis of 57 clinical studies indicates that probiotic administration in immunocompromised adults is safe with regard to the current evaluated probiotic strains, dosage and duration. There were no major safety concerns in the study, and overall, adverse events occurred less frequently in immunocompromised subjects receiving probiotics compared to the control group.

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I Was Doing Great On My Maintenance Dose Until

Life happens and this can derail gut balance. Things like travel, stress or a significant period of poor self-care might lead to a regression. If this happens, its OK. It happens. No one is bulletproof. Simply return to the full Probiotic Triple Therapy protocol, and then later you can again wean your dose.

What Is Autoimmune Disease

Probiotics: An In

Autoimmune disease is an autoimmune condition that causes your immune system to attack the organs in your body as opposed to guarding them. In people without an autoimmune condition, the immune system is one of the best defenses a person has against viruses and bacteria.

Whenever your immune system determines that a certain invader is a threat to your health, it sends out white blood cells to go and attack, even eliminate that threat, thus protecting you from diseases.

Your immune system is designed with an internal radar to help it differentiate between potentially threatening foreign bodies or orgasms and your own immune cells. Unfortunately, in people with autoimmune diseases, this internal radar is faulty, and in many cases, their immune system continuously attacks their own cells by mistake.

In this case, the autoimmune disease causes their immune system to mistakenly attacks parts of their bodies such as their knees, joints, skin by releasing autoantibodies and sending them out to attack otherwise healthy immune cells.

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Probiotics And Autoimmune Disease

Our immune systems protect our bodies from outside threats, eliminating foreign cells that try to enter our bodies. Sometimes, however, this line of defense cant tell the difference between our cells and those that need to be eliminated. This results in at least 1 of 80 different autoimmune disorders that involve the immune system attacking the bodys normal cells.

Digestive issues are among the common symptoms of autoimmune disorders. Several studies have shown that probiotics can help manage both gastrointestinal symptoms and inflammation associated with autoimmune disorders like multiple sclerosis, rheumatoid arthritis, and ulcerative colitis. In addition, other conditions like psoriasis, Crohns disease, diabetes, and celiacs could potentially benefit from the use of probiotics.

Probiotics In Autoimmune Diseases

Studies suggest that probiotics influence systemic immune responses, ensure the homeostasis of the healthy microbiota in the intestinal mucosa, and could, therefore, be used as adjuvant therapy to treat immune-mediated diseases . The mechanisms proposed to achieve this include mucus secretion, antimicrobial peptide production, the maintenance of the function of the gastrointestinal-epithelial barrier, decreasing oxidative stress, ensuring adequate interactions between the gut microbiota and the mucosal immune cells, and, finally, helping the activation of host immune system in response to pathobionts .

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How To Use This Probiotic

L. casei is naturally found in the gut. Some fermented foods contain L. casei, too. These include some yogurts, yogurt-like fermented milk, and certain cheeses.

Dietary supplements containing L. casei and other probiotics can be found in health food stores or wherever dietary supplements are sold. When shopping for probiotics, it pays to read labels carefully. Follow directions for storage and take expiration dates seriously.

Studies regarding dosage are lacking. There are no definitive guidelines. Read product labels carefully and ask your physician or pharmacist how much you should take.

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Lactobacillus rhamnosus (LGG®) – the world’s best documented probiotic strain

Nevertheless, few research studies have actually looked at the safety of probiotics in detail, so there’s a lack of strong information on the frequency and severity of side results. The threat of damaging effects from probiotics is higher in individuals with severe illnesses or compromised body immune systems. When probiotics are being thought about for high-risk people, such as early infants or seriously ill hospital clients, the possible dangers of probiotics must be carefully weighed against their benefits – best probiotic supplement for yeast infections.

Some probiotic items have actually been reported to consist of microbes besides those listed on the label . In some circumstances, these impurities might pose major health threats. NCCIH sponsors a variety of research tasks connected to probiotics or the microbiome. In addition to the formerly discussed studies on diet-microbiome interactions in the gastrointestinal tract, current topics consist of: The mechanisms by which probiotics may assist to decrease postmenopausal bone loss Engineering probiotics to synthesize natural substances for microbiome-brain research study The systems by which specific probiotics may alleviate chronic pelvic discomfort The effects of a particular Bifidobacterium stress on modifications in short-chain fatty acid production in the gut that may play a function in antibiotic-associated diarrhea.

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What Are The Benefits Of Lactobacillus Casei

When you dont have enough of the good bacteria, adding more L. Casei to your dietcan help regulate your digestive system.

Probiotic supplements containing L. Casei are used to prevent or treat diarrhea. This includes infectious diarrhea, travelers diarrhea, and antibiotic-associated diarrhea.

It may also have some effect on other digestive problems, including:

  • colic

looked at people with Parkinsons disease. That one revealed that regular intake of milk fermented with Lactobacillus casei Shirota can improve bowel habits of people with the disease.

Researchers for a 2014 clinical trial found that L. casei supplements can help alleviate symptoms and improve inflammatory cytokines in women with RA.

There is a growing body of research into L. casei and other probiotics. But to date, the U.S. Food and Drug Administration hasnt approved L. casei or any other probiotic for the treatment of a specific health problem.

Amazon Best Sellers: Best Probiotic Nutritional Supplements

When recommending certain probiotic products, it is necessary to inform clients that they should include the particular live microbes in adequate amounts as shown in the literature to receive the health benefits. This article examines six popular probiotic supplements individuals can select to help improve their gastrointestinal health. It goes over the evidence supporting these items, and supplies therapy tips on what to advise to customers and patients for particular conditions.

Line up Align brand probiotic supplement consists of Bifidobacterium infantis 35624, which has actually been revealed to lower symptoms such as bloating, cramping, and stool frequency in those with irritable bowel syndrome . In a study of 362 clients with IBS, those who took B infantis 35624 experienced a significant decrease in symptoms.

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What Is Rheumatoid Arthritis

Arthritis can be informally explained as inflammation of one or more joints, causing pain and stiffness that can worsen with age. It is not a single disease but a cluster of many painful symptoms that affects joints and bones.

Rheumatoid arthritis and osteoarthritis are the two major types of arthritis. Rheumatoid arthritis is autoimmune in nature and inflames joints and other musculoskeletal areas. Organ damage and disability is not uncommon in this type of arthritis.

Osteoarthritis is the most common form of arthritis prevalent in the world and is mostly driven by age. Protective cartilage on bones of hands, knees, hips, and spine erodes, causing disability.

The cause of arthritis has baffled researchers for decades, but a new line of thought has begun associating it with the gut microbiome.

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