The Best Probiotic For Inflammation
At BlueBiology, were well aware of how many health issues are caused by chronic inflammation. From chronic fatigue to insomnia, weight issues, body aches, indigestion, anxiety, frequent infections, and even psychological issues like anxiety and depression, chronic inflammation can have a serious negative impact on your quality of life.This is why we formulated BlueBiotics Ultimate Care with chronic inflammation in mind. There are just so many health issues cause by and related to chronic inflammation. BlueBiotics contains 12 of the most efficient probiotic strains that have the widest range of health benefits. And the best part is that each and every one of these probiotic strains has been shown to reduce inflammation in scientific testing. The probiotic strains that reduce inflammation in BlueBiotics Ultimate Care include:
- Lactobacillus acidophilus complex
- Bifidobacterium lactis complex
- Bifidobacterium breve complex
If youre serious about living a healthier life free of chronic inflammation and all its unfortunate side effects, be sure to check out what we sincerely believe is the best probiotic for inflammation, BlueBiotics Ultimate Care.
Best Probiotics For Autoimmune Disease
While assessing the quality of different probiotic supplements for autoimmune disorders, we evaluated quality, brand history, reviews, third-party testing, and certificates. We also focused on CFU , as it is one of the most important factors for probiotics. CFU estimates the number of live bacteria in each sample and is commonly used in microbiology.
Best Rated Probiotic Supplement
Summary And Clinical Applicability
Study participants with RA who took probiotic supplements for 8 weeks had improvements in DAS-28 scores, decreased levels of serum insulin, HOMA-B, and hs-CRP levels relative to treatment with placebo. No detectable changes were found in fasting plasma glucose, quantitative insulin sensitivity check indices, homeostatic model assessments of B cell function, or plasma nitric oxide.
Probiotic intake may improve clinical and metabolic status in RA patients through its anti-inflammatory effects both locally in the gut and systemically, the authors concluded.
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What Happens In Ra
Nearly 1.5 million people in the United States have rheumatoid arthritis, according to the Centers for Disease Control and Prevention. RA is an autoimmune disease. This means that in RA, the immune system, which is supposed to protect the body from bacteria, viruses and other foreign pathogens, mistakenly attacks the joints.
These repeated attacks cause inflammation in the tissue that lines the inside of your joints, known as the synovium, which is a very thin layer of cells that help your joints move smoothly. Constant inflammation leads to thickening of the synovium and you get swelling and pain in and around your joints. Normally, the synovial lining is only one to three cells thick but it can be up to eight to ten cells thick in someone with RA due to the swelling and thickening. Chronic inflammation from RA can cause:
- Loss of function in your fingers
- Wrists or other joints.
Specific Strains Of Bacteria That May Affect Ra
Research has previously shown a link between RA and the bug Prevotella copri. A study published in the journal eLife found that the intestines of 75 percent of people with early, untreated rheumatoid arthritis had this bacterium in their intestines compared with 12 percent of people with chronic, treated rheumatoid arthritis. The theory is that this bacteria crowds out beneficial microbiota that fight inflammation or itself promotes inflammation.
Another study, published in April 2017 in Arthritis & Rheumatology, examined whether the overexpansion of Prevotella copri in the gut has the potential to affect immune cell functions, contributing to the development of RA. Study authors found that there is evidence for immune relevance of P. copri in RA. At this point, experts cant claim that P. copri causes RA, but the research provides an intriguing path for future study, according to an article published in November 2019 in the Journal of Clinical Medicine.
A different strain of the bacteria, Prevotella histicola, may actually decrease symptoms and disease progression, according to research done by Mayo Clinics Center for Individualized Medicine, published in April 2016 in Genome Medicine. Mice who were given the bacteria saw a delay in the disease and a reduction in the amount of cytokines in their system.
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Best Probiotics For Rheumatoid Arthritis
By Robb | Last Updated
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Whilst we all may experience painful joints, fatigue and loss of appetite once in a while, these are symptoms that rheumatoid arthritis sufferers experience every single day
And even though the severity of rheumatoid arthritis differs from person to person, Im sure that each and every one of the 1.5 million US citizens who suffer from it will agree that it sucks.
Now, the bad news is that rheumatoid arthritis is incurable.
In other words, once youre diagnosed with it, youll probably have to deal with it for the rest of your life.
But the good news is that a lot of the troubles people with rheumatoid arthritis face can be minimized by living a healthy, low inflammation lifestyle, as well as using certain supplements, such as probiotics.
Effects Of Probiotics In High
In both animal trials and human trials, probiotics have been investigated to determine potential beneficial effects in the prevention and treatment of a wide variety of systemic conditions. These conditions include inflammatory and autoimmune diseases such as rheumatoid arthritis, ulcerative colitis, multiple sclerosis, and hepatic encephalopathy. Advantages of probiotics include the regulation of immune system function, which is often dependent on the strain of probiotic bacteria. Some strains have demonstrated stimulation of the immune response, thereby being beneficial to patients suffering from immunodeficiency . Other strains have been shown to inhibit the immune response, thereby being beneficial for patients suffering from conditions with immune activation such as rheumatoid arthritis .
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How Good Bacteria Keep You Well
They remove bad bacteria. They getrid of the nasty bacteria that enter the digestive tract, preventing them from multiplying and making us unwell. Goodbacteria produce lactic acid and fatty acids which lowers the acidity in the large bowel, making it difficult for badbacteria to over-multiply. This helps keep a healthy balance of bacteria.
They aid digestion. Good bacteria break down fibre in the gut to produce nutrients forthe cells that line the bowel, keeping your gut healthy.
They make vitamins. You get most of your vitamins from food, but the healthy bacteria in our body make some too, such ascertain B vitamins and vitamin K.
They attack infections. Around 70 per cent of our immune system is in our digestive system. When we have a virus. Ourhealthy bacteria leap into action, aiming to neutralise toxins that the virus makes, thus reducing the likelihood that the virus willprogress.
Ministry Of Health Monitors The Current Situation
The Ministry of Health uses the Early Warning and Response System. It is a closed system, thanks to which MoH can continuously communicate with other countries on a daily basis. Furthermore, the MoH participates in regular teleconferences of the EU Health Security Committee , where information is shared. In particular, information on the epidemiological developments and teleconferences are provided by expert and relevant statements from the World Health Organization and the European Center for Disease Prevention and Control .
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Is There A Link With Bacteria And Arthritis
A study published in 2013 in the U.S. found that people with rheumatoid arthritis were much more likely to have a bug called Prevotellacopripresent in their gut than people that did not have the disease. Another study, completed in 2014, found that patients with psoriaticarthritis had significantly lower levels of other types of gut bacteria.
These findings suggest that certain bacteria may be linked to triggering the autoimmune response that leads to joint inflammation. Studieshave also found that leaky gut syndrome, or other gastrointestinal problems, could trigger flare ups in conditions such asrheumatoid arthritis and lupus.
Probiotic Supplementation For Rheumatoid Arthritis: A Promising Adjuvant Therapy In The Gut Microbiome Era
- 1Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- 2Serviço de Reumatologia e Doenças Ósseas Metabólicas, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa , Lisboa, Portugal
- 3Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, CAML, Lisboa, Portugal
- 4Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
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Benefits Of Probiotics And Rheumatoid Arthritis
Probiotics or beneficial bacteria are known to promote a number of healthy body functions and there is a medically established link with probiotics and rheumatoid arthritis.
Lately, new research suggests probiotics to be an effective therapy in various types of arthritis because of their immunity-boosting and anti-inflammatory properties. Keep reading to understand arthritis, probiotics, and how probiotics can help mitigate the symptoms of arthritis.
Human beings have billions of bacteria that inhabit their skin, mouth, gut, and other parts of the body. Most of this bacteria is good though, while some can be harmful.
Benefits Of Probiotics In Rheumatoid Arthritis
Arthritis is a widespread disease which effects the joints weakens them.
It is generally characterized by joint pain, swelling and inflammation.
It occurs most commonly in the two chronic forms- osteoarthritis and rheumatoid arthritis.
Other forms of this disease include septic arthritis, gout and reactive arthritis. Many disorders of the connective tissues are also categorized as arthritic problems.
Rheumatoid arthritis comprise of a painful and progressive onset. It is an inflammatory form of the disease.
As it spreads, it leads to nodule and lump formation. This are poses a threat to the lungs and eyes.
The disease is found to run in families which is why some scientists believe that it is a genetic issue as opposed to osteoarthritis which is brought about by wear and tear of joints.
This genetic problem can get triggered on exposure to certain damaging environmental factors such as smoking.
Symptoms consist of a general feeling of malaise and flare-ups at the joint sites.
The proper diagnosis is carried out through X rays or magnetic resonance imaging followed by a blood test to eliminate other disease and determine the specific problem.
The objective of rheumatoid arthritis treatment is to heal by reducing pain, inflammation and improving the function of the joint.
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Recognized Benefits In The 1900s
The term probiotic was introduced in 1953 by the German Werner Kollath to mean active substances essential for a healthy life . In the 1940s, most research focused on culturing pathogenic bacteria and developing antimicrobial therapies. In line with this approach, after the 1950s, there was great interest in identifying probiotics that provided colonization resistance to pathogens, and research began to focus on lactobacilli and bifidobacilli to combat diarrheal disease. This research focused on the role of probiotics and gut health and resulted in convincing evidence that probiotics can prevent and treat infections causing diarrhea and also facilitate peptic ulcer healing .
Dosage Of Probiotics In Rheumatoid Arthritis
Nutritionists and dieticians suggest that the best mode of introduction of probiotics into our system is by means of modifying our diet.
This can be carried out by eating probiotic-rich yogurts and adopting a Mediterranean diet which is rich in fish, olive oil and vegetables.
Some studies also claim that vegan diets offer probiotic advantages. They have been found to alter the gut microbiome and reduce the harmful effects of Rheumatoid Arthritis.
If opting for supplements, consult a health practitioner prior.
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Probiotics Help Improve Joint Activity
The swelling and weakness at joints renders them inactive. Scientist aimed to study the ability of probiotics in reversing this occurrence.
For this purpose, patients affected with rheumatoid arthritis varying in age from 18 to 40 were involved in a study. They were randomized into a placebo group and a treatment group.
The two groups took 2 capsules daily for 3 months. The treatment group was given the probiotic Lactobacillus. Tests were carried out on the 0th, 45th and 90th day.
It was seen that the treatment group had highly benefited when compared to the placebo group. Their joints were healthier enabling their limbs to be more active and mobile.
What does this mean? This implies that supplementation of probiotics in arthritis patients diet reverses swelling and damage to tissues therefore aiding the agility of limbs.
Measurements At The Congress
The Prague Congress Centre will equip all bathrooms, cloakrooms, info desks and entrance areas with disinfection gels. They will increase the frequency of cleaning of the congress spaces. Their air condition system is based on a 100% air exchange when the old air is being let out and a new air is being drawn in on another side of the building. This may also avoid spreading the disease through ventilation.
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Probiotics Maintain Bone Health
One of the mains symptoms of arthritis is progressive deterioration of cartilage tissue.
This occurs due to the activity of enzymes which catalyse the destruction of tissue over time.
An experiment aimed at understanding how probiotics effect metabolic responses in arthritic patients was carried out using a group of 60 subjects.
The individuals ranged from age 25-70.
Half of the group were given prebiotic capsules containing Lactobacillus acidophilus, Lactobacillus casei and Bifidobacteriumbifidum daily for 8 weeks.
The other half were given placebos.
At the end of the study, the group who were given the prebiotic capsules showed positive results in the form of decrease in serum insulin levels and serum high-sensitivity C-reactive protein concentrations- metabolic markers of rheumatoid arthritis.
What does this mean? From this study, it can be inferred that probiotics maintain a check on arthritic enzymes thereby delaying cell destruction.
Are There Any Evidences Supporting The Role Of Probiotics In Rheumatic Diseases
Although still limited, there’s a growing interest in the possible use of probiotics in rheumatic diseases. We discuss here the evidence deriving from RCTs conducted in chronic conditions including RA, OA, gout, and SpA . These studies have been addressed to the investigation of the effect of oral probiotic administration in ameliorating systemic inflammatory markers and disease activity indices.
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What The Research Says
A study published in the journal Nutrition observed the effects of probiotics on 46 patients with rheumatoid arthritis. The patients were divided into two groups, where one group was given daily supplements containing Lactobacillus casei, while the others were given a placebo.
Several markers of inflammation were found to be significantly reduced in the probiotic group after an 8-week period. This led researchers to state that pending further research probiotics could be used as an adjunct therapy to treat patients with arthritis.
Another study published in PLOS One asserted that the gut microbiome could be a potential indicator of susceptibility to arthritis after the researchers determined which animals were more susceptible to developing RA and collagen-induced arthritis .
A review article published in Current Opinion in Rheumatology stated that targeting the gut microbiota could be a viable therapeutic option to target some forms of inflammatory arthritis.
A study on mice published in the Journal of Interferon & Cytokine Research found that Lactobacillus casei and Lactobacillus acidophilus reduced joint inflammation more effectively than the NSAID indomethacin.
Experimental Evidence From Human Studies
Randomized Controlled Trials With Lactobacillus rhamnosus
The effect of probiotic supplementation was studied in stable RA in a randomized controlled trial evaluating the treatment with Lactobacillus rhamnosus GG versus placebo . Patients were not under treatment with DMARDs, but most of them were on stable medication with glucocorticoids and non-steroidal anti-inflammatory drugs . In this study, the intervention group was given two capsules of L. rhamnosus GG per capsule), twice a day, for 12 months, and the placebo group received identical capsules without the bacteria. There were no statistical differences in the clinical parameters, biochemical variables, and Health Assessment Questionnaire between groups. Inflammatory parameters were not significantly reduced. Interestingly, although there were no statistical differences in disease activity, more subjects in the intervention group reported subjective well-being when compared to the placebo group .
Randomized Controlled Trials With Lactobacillus casei
Randomized Controlled Trials With Bacillus coagulans
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Fermented Foods As A Possible Alternative To Probiotic Supplements
Fermented foods and beverages are defined as foods made through desired microbial growth and enzymatic conversions of food components . Yoghurt, Kefir, Miso, Natto, Tempeh and most Kombuchas are some of the available fermented foods that contain live microorganisms . Historically, many foods have undergone fermentation as a food preservation technique since the generation of antimicrobial metabolites like organic acids, ethanol and bacteriocins reduce the risk of contamination with pathogenic microorganisms . Nowadays, fermented foods and beverages are more popular than ever before . This emerging interest in such foods could be explained by their health-promoting potential .
Although the current body of evidence regarding the impact of fermented foods on health and disease remains insufficient , it is increasingly understood that some fermented foods promote human health in ways not directly attributable to the starting food materials . These foods could benefit health through the nutritive alteration of the ingredients, modulation of the immune system, or by influencing GM composition and activity . Most likely, several of these mechanisms are related and contribute to the effects of each other.
Polarization Within The Medical Community Regarding The Use Of Probiotics
The medical community has not yet endorsed the use of probiotics. In fact, the U.S. Food and Drug Administration has not yet approved any probiotics for preventing or treating any health problem. Despite the numerous evidence-based reviews and meta-analyses cited herein, there are legitimate reasons for caution. Many of the meta-analyses suffer from the practice of lumping together different probiotics which may have widely different mechanisms of action. Some experts have warned that the rapid growth in the marketing of probiotics may have outpaced scientific research for many of their proposed uses and benefits . More concerning is that there have been rare reports of bacteremia with cultures positive for the probiotic administered, leading to probiotic-associated endocarditis and even death. One notable case involved an infant who developed invasive mucormycosis, leading to intestinal perforation and death, resulting from a probiotic which was contaminated with a fungus, Rhizopusoryzae . However, overall, probiotic groups compared with matched placebo-treated controls have often shown a reduction in sepsis rates, as shown in preterm infants and in adults following gastrointestinal surgery .
There are other concerns among skeptics.
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