Good Vs Bad Postbiotic Metabolites
In this article I am only focusing on postbiotic metabolites produced by beneficial probiotic bacteria. However, pathological bacteria also produce postbiotic metabolites. The difference is that the postbiotic metabolites produced by probiotic bacteria have beneficial health-regulating effects, whereas the postbiotic metabolites produced pathological bacteria have toxic effects. Thats why certain strains of bacteria are pathological, it is their postbiotic metabolites that are toxic.
This is why it is so important for people to learn how to create and maintain a healthy microbiome. A healthy microbiome consists of predominantly beneficial probiotic bacteria. The postbiotic metabolites from strains of probiotic bacteria create a microbiome ecosystem that supports the growth and proliferation of probiotic bacteria and inhibits the growth of pathogens.
The National Microbiome Initiative
In May 2016, the White House Office of Science and Technology committed to continue research into the vast new frontier in microbiome science by announcing funding for the National Microbiome Initiative. This program is sponsored with $121 million in funding from Federal agencies and an additional $400 million from non-government institutions.3
Add Dr Ohhiras Probiotics To Your Ongoing Plan For Whole Health And Reap The Benefits:
- Balance and support your personal unique bacterial fingerprint*
- Relieve occasional gas and heartburn*
- Maintain healthy intestinal pH and digestive function*
- Support the absorption of nutrients from food and other supplements*
- Support a healthy immune system response*
- Convenient blister-packed capsules are stable at room temperature
- Live and viable bacteria NEVER freeze-dried
- Immune System Support*
- In addition to supporting digestion, probiotics are essential for immune system function. Your gut is your first line of immune response. Approximately 70-80 percent of immune system cells reside in the digestive tract, and probiotics support those immune cells.*
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Postbiotic Metabolites: How Probiotics Regulate Health
The purpose of this article is to present the latest information on postbiotic metabolites, which are compounds that are produced by bacteria as they digest fiber-rich foods in the intestinal tract. Gradually over the past two decades, scientific studies have been gradually unraveling the mystery of how probiotic bacteria influence human health. We are learning that different types of postbiotic metabolites regulate different aspects of human health. The emerging new story in microbiome science is that postbiotic metabolites are increasingly being understood to be master health-regulating compounds for human health.
Seismic Shift In Microbiome Science
Much of the emphasis in microbiome science is shifting from Who Is There to What Is Done There.27 Scientist continue to discover new postbiotic metabolites and the way these compounds function. Thus, we are learning that postbiotic metabolites are the mechanism of action by which probiotic bacteria regulate a wide range of human functioning.
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Reviews For Dr Ohhiras Probiotics Original Formula 60 Caps
joe March 7, 2016
Purchased this product a while ago. Wanted to try it out before giving it a review. Works great, as advertised, and so far no problems whatsoever. Would recommend to a friend!
Heidi March 26, 2016
This product was recommended to me by my doctor 10 years ago. I have been using it since and am extremely pleased. It has positively impacted my overall health. I finally convinced my husband to start taking it and often recommend it to friends who are health minded.
Ann Harper April 3, 2017
Id give this product a 5 but because the price has gone up so much I am going elsewhere to but for $15 less a box..what gives?????
Directly Ingesting Postbiotic Metabolites
When people directly ingest postbiotic metabolites, those compounds immediately begin to exert their health-promoting effects when they arrive in the small intestines. Here are some of the better-known health effects of postbiotic metabolites:
- Antimicrobial peptides kill pathogens critical aspect of immune system49
- SCFAs play important roles in regulating the immune system50
- Weakly acidic compounds create the optimal intestinal acid/base balance51
- Hydrogen peroxide suppresses the growth of fungi and yeasts like candida52
- Fulvic acids bind and transport minerals into cells.53
- SCFA butyrate is the primary energy source for epithelial cell growth54
- Glutathione has powerful antioxidant, detoxification & immune system enhancing effects55
- Phytoestrogens equol/enterolactone/enterodiol bind to estrogen receptors: lower menopausal symptoms & risks to many diseases56
- Probiotic-produced nutrients : wide range of benefits associated with these nutrients57
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Probiotics And Cancer Prevention: A Conversation With Ross Pelton Rph Ccn
This article is part of the 2018 NMJ Oncology Special Issue. .
In this podcast episode, we speak with Ross Pelton, RPh, CCN, about the variety of mechanisms of action that probiotics have when it comes to reducing cancer risk. Pelton also talks about colon cancer, H. pylori, and probiotic safety and dosage. Finally, he describes how to support a healthy microbiome with a healthy lifestyle.
Dr Ohhiras Probiotics: Directly Delivering Postbiotic Metabolites
Dr. Ohhiras Probiotics is a fermented food product that is produced utilizing a multi-year fermentation production process under strict cleanroom conditions. Dozens of different kinds of organically grown foods are shredded and added to large 80-gallon fermentation vats along with 12 strains of carefully selected synergistic strains of probiotic bacteria.
There are two versions of this fermented food probiotic. Dr. Ohhiras Probiotics: Original Formula undergoes three years of fermentation and this product is sold at the retail level in fine health food and vitamin stores throughout the United States. Dr. Ohhiras Probiotic: Professional Formula undergoes an additional two years of anaerobic fermentation, for a total of five years of fermentation. Over 99% of your microbiome consists of anaerobic bacteria that reside in your large intestines and colon. The additional two years of anaerobic fermentation results in the production of larger amounts of the postbiotic metabolites from the anaerobic bacteria. The Professional Formula is primarily marketed to healthcare professionals.
Recent research conducted by an independent laboratory in Japan reported that Dr. Ohhiras Probiotics contain over 500 different postbiotic metabolites.58 Each capsule contains live probiotic bacteria, some of the prebiotic foods used during the fermentation process, which continue to support the bacteria, and most importantly, a multitude of postbiotic metabolites.
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An Analogy: Manufacturing Vs Microbiome
The auto manufacturing industry produces vehicles such as cars, trucks, SUVs and vans. The workforce consists of many hundreds of employees with a wide variety of skills and talents. However, this workforce is largely ineffective if they dont have on hand the thousands of parts that are required to produce different kinds of vehicles.
Similarly, the human microbiome contains between 500 to 1000 species totaling an estimated 100 trillion bacteria.18 The probiotic bacteria are like the skilled employees in a manufacturing plant, but your probiotic workers must have a wide variety fiber-rich food available in order to create the desired end products, which are the postbiotic metabolites. Probiotic bacteria are primarily a workforce, and their job is to build or create postbiotic metabolites.
The Fiber Gap: Americas #1 Nutritional Deficiency
Fiber is the required food for probiotic bacteria. Dietary fibers contain carbohydrates that our human digestive system cannot metabolize. Hence, these dietary fibers pass through the small intestines unchanged. However, when they arrive in the large intestines, fibers become the primary food for probiotic bacteria. Anaerobic probiotic bacteria that reside in the large intestines produce specialized enzymes which enable them to breakdown plant-based fibers, resulting in the production of postbiotic metabolites.
A book titled The Good Gut12 provides a much deeper discussion of how important dietary fiber is to the maintenance of a diverse microbiome. The books author Justin Sonnenburg suggests that dietary fiber is an imprecise term and he proposes using the term, microbiota accessible carbohydrates or MACs. Thus, a BIG MAC diet is a diet that contains fruits, vegetables, legumes and unrefined whole grains, which are rich in the fibers required by various strains of probiotic bacteria.
The quantity of fiber in the American diet is not the only fiber issue. A wide diversity of fiber-rich foods is required to promote the growth of a diverse microbiome. How many different types of multi-colored, fiber-rich foods are you feeding your probiotic bacteria today?
Many people take probiotics. However, since most Americans are not consuming fiber-rich diets, it is likely that many people dont get much benefit from the probiotics they are taking.
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A Healthy Microbiome: Two Pieces To The Puzzle
The ONLY way you can achieve a diverse microbiome is to consume a diverse range of fiber-containing foods. Dietary fiber is the food for your probiotic bacteria. Different strains of bacteria require different types of fiber, which results in the production of a diverse range of postbiotic metabolites. Thus, it takes more than probiotic bacteria to create and maintain a healthy microbiome. It takes bacteria + fiber. If you dont learn how to feed your probiotic bacteria well, they will not thrive and survive.
Dr Ohhiras Probiotics Original Formula By Essential Formulas Is A Unique Blend Of:
- PREbiotics Culture Medium fermented vegetables and mushrooms that nourish the probiotics*
- PRObiotics friendly bacteria that help you digest food and support immune response*
- POSTbiotics pH balancing organic acids along with naturally occurring vitamins, minerals, enzymes, and amino acids to support digestive function and whole health*
For best results take one capsule twice a day on an empty stomach or as directed by your primary health care provider. One box supply will last approximately one month. Expiration date is approximately 3 years from date of purchase.
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Postbiotic Metabolites: The New Frontier In Microbiome Science
For decades, we have known that probiotic bacteria play important roles in the regulation of health. However, until recently, the mechanisms that explain how probiotic bacteria regulate so many aspects of human health have remained elusive.
In the past several decades, scientists have been discovering that probiotic bacteria are amazingly complex little chemical manufacturing plants. The primary function of probiotic bacteria is to digest and ferment dietary fibers, which results in the production of a wide range of health-regulating compounds that known as postbiotic metabolites.
The terms postbiotics5,6 and postbiotic metabolites7 are increasingly appearing in the title of scientific studies. In The Mind-Gut Connection, author Emeran Mayer, MD states that our bacteria utilize the information in their millions of genes to transform the food into hundreds of thousands of metabolites.8 This is the vast new frontier in microbiome science.
Drohhira Standard Probiotics 30 Capsules / Dietary Supplement
Dr.OHHIRA® capsules contain 12 types of live probiotic cultures that are compatible with each other and have achieved the best results in scientific research. The main nuance that makes Dr.OHHIRA® probiotics unique is the fact that Dr. OHHIRA® capsules are not primarily lactic acid bacteria in a capsule, but fermented foods that contain postbiotic compounds, a prebiotic fiber blend, and like all fermented foods, probiotics.
- A unique synbiotic trio: of pro-, pre- and postbiotics
- 100% natural raw materials
- Natural production process by 3-year fermentation
- Herbal capsules are also suitable for vegans
Ingredients: molasses, oligosaccharides, European plum extract , spinach leaf extract, Goji fruit extract, shiitake powder, mustard spinach leaf and stem extract, fig extract, rabbiteye blueberry berry extract, Chinese bayberry fruit extract, yuzu extract, Agaricus mushroom powder, maitake powder, seaweed extract, seaweed extract, algae extract Bifidobacterium , Lactobacillus , S.thermophilus NBRC13957 safflower seed oil, seaweed extract, vegetable oil , emulsifier glycerin fatty acid ester starch, thickener carrageenan, the humectant glycerin, dye caramel .
Dr.OHHIRA® probiotics do not contain artificial additives, chemicals, preservatives, dyes, flavors, animal by-products, pesticides or herbicides. GMO free. Does not contain dairy products. Gluten-free and hypoallergenic.
Made in Japan.
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The Benefits Of Bacterial Fermentation
Fermentation has been used for centuries as a method of preserving food.19 During fermentation, bacteria break down sugars, carbohydrates and fibers in foods and convert them into a class of postbiotic metabolites named short-chain fatty acids . These slightly acidic compounds suppress the growth of pathogens, which preserves the food. The same process takes place in the human gut. Bacteria ferment dietary fibers, which results in the production of weakly acidic compounds that suppress the growth of pathogens. Hence, probiotic bacteria regulate an important part of our immune system.20
Studies in microbiome science continue to discover new kinds of postbiotic metabolites with varying health-regulating effects. In fact, human clinical trials have revealed strong associations between consumption of fermented foods and improved health for conditions such as obesity21, type 2 diabetes22, hyperlipidemia23, hypertension24, osteoporosis25, and depression.26 These studies emphasize that postbiotic metabolites in fermented foods or that are created when probiotic bacteria ferment dietary fibers in the an individuals GI tract, have important health-regulating effects far beyond just gut health.
A Revolution In Microbiome Science
The Human Genome Project was a 13-year , $3 billion-dollar project that resulted in the first successful sequencing of the human genome. One of the major goals of the Human Genome Project was to find cures for the chronic degenerative diseases that currently plague mankind. Unfortunately, that goal was a complete failure because to date, sequencing the human genome has not led to successful treatments for any diseases.
Although cures for diseases did not materialize, scientific advancements during the 1990s and the first two decades of the 21st century resulted in the development of vastly faster, more powerful gene sequencing technologies along with huge reductions in cost. The speed of these technological advancements is unprecedented in the history of science.
Heres a summary of these remarkable achievements. The sequencing of the first human genome took 13 years and cost nearly $3 billion dollars. In January 2017, Illuminia, which is the worlds leading producer of next-generation sequencing technology, announced that their new NovaSeq machine can sequence an entire human genome in less than one hour for $100.1 Hows that for mindbogglingly fast scientific advancement? What originally took over a decade and cost billions of dollars can now be done is less than an hour for $100. These exponential increases in gene sequencing technology have ushered in a revolution in microbiome science.
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Drohhira Deluxe Probiotics 30 Capsules / Dietary Supplement
Dr. OHHIRA® Formula is a unique blend of:
- 12 strains of lactic acid bacteria carefully selected from more than 180 kinds.
- Botanical extract. A combination of vegetables, fruits, seaweeds and mushrooms naturally fermented for 5 years that nourish your friendly bacteria.
- Biogenics. Intestinal pH balancing organic acids along with naturally occurring vitamins, minerals, dietary fibers, oligosaccharides and amino acids.
Ingredients: Molasses /oligosaccharide, Prunus domestica, Spinacia oleracea L., Lycium chinese, Lentinula edodes , Brassica rapa var. perviridis, Ficus carica L.,V. ashei Reade, V. australe Small, Myrica rubra, Citrus junos SIEB. ex Tanaka, Agaricus blazei, Grifola frondosa , Hizikia fusiforme, Undaria pinnatifida, Laminaria japonica, B.breve ss. Breve M-16V, B.infantis ss. Infantis M-63, B.longum BB536, B.lactis Bl-04®, L.acidophilus La-14®, L.brevis NBRC 3345, L.bulgaricus NBRC 13953, L.casei TO-A, L.fermentum NBRC 3071, L.helveticus NBRC 3809, L.plantarum TO-A, Streptococcus thermophilus NBRC 13957, Safflower oil, Seaweed power, Vegetable oil, Glycerine fatty acid ester, Starch, Carrageenan, Glycerin, Caramel.
Usage: The product is suitable for people of all ages. It is advisable to squeeze out the contents of the capsule children under 3 years of age. Adults and children are advised to take 1-2 capsules a day, 40 minutes before or 2 hours after a meal. After all, you should drink water.
Made in Japan.
The Genome Complexity Conundrum
The successful sequencing of the human genome revealed that humans have about 23 000 genes. This number much smaller than the number of genes scientists expected to find in the human genome. This resulted in a perplexing puzzle that is called the Genome Complexity Conundrum.4
The puzzle was due to the fact that whereas humans have about 23,000 genes, the common rice plant has about 45 000 genes. Experts were shocked when they realized that the common rice plant has nearly twice as many genes as humans. Scientists began scratching their heads and wondering, If we humans are as complex and evolved as we think we are, how can it be that we only have half as many genes as the common rice plant?
The solution to the Genome Complexity Conundrum began to emerge when studies began to reveal that the human intestinal microbiome consists of an estimated 100 trillion bacteria, and on average, humans harbor from 500-1000 different species of bacteria in their GI tract. These intestinal bacteria contain approximately 3.3 million non-repeating genes, compared to the 23 000 genes in the human genome. It is amazing to realize that over 99% of the DNA in your body is the DNA of your bacteria. This helps explain why humans only need 23 000 genes, because massive amount of DNA in the genes of your probiotic bacteria regulate a great deal of your biological activity.
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The Human Microbiome Project
The amazing power and speed of the new gene sequencing technologies were partly responsible for the funding of the Human Microbiome Project .2 Funding from The Human Microbiome Project has resulted in the publication of over 350 studies. This flood scientific publications on probiotics and microbiome science is viewed as the birth of the modern era of microbiome science.
Ingesting Probiotics Vs Postbiotics
Commercial probiotic products simply contain one or several strains of probiotic bacteria that are delivered in a capsule, tablet or in foods such as yogurt or kefir. However, in order to be effective, those bacteria must survive transit through the harsh acidic environment in the stomach. Then, when they arrive in the small intestines, they must locate fiber-rich foods and begin the process of digesting/fermenting those fibers into postbiotic metabolites. This process takes a substantial amount of time. And, remember, most Americans dont consume nearly enough fiber-containing foods, which compromises the probiotic bacterias ability to produce postbiotic metabolites.
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